Detailed information of TA system TA128126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 87008..87643
• Replicon: plasmid pA
• Accession: NZ_CP041349
• Organism: Komagataeibacter xylinus strain CGMCC 17276

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FMA36_RS17265
• Protein ID: WP_159264234.1
• Coordinates: 87233..87643 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FMA36_RS17260
• Protein ID: WP_159264233.1
• Coordinates: 87008..87232 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FMA36_RS17230	82379..82780	+	402	WP_159264226.1	nuclear transport factor 2 family protein	-
FMA36_RS17235	82816..83265	+	450	WP_159264227.1	SDR family oxidoreductase	-
FMA36_RS17240	83679..84557	-	879	WP_159264229.1	NmrA/HSCARG family protein	-
FMA36_RS17245	84666..85562	+	897	WP_159264230.1	LysR family transcriptional regulator	-
FMA36_RS17250	85904..86374	+	471	WP_159264231.1	hypothetical protein	-
FMA36_RS17255	86403..86735	-	333	WP_159264232.1	hypothetical protein	-
FMA36_RS17260	87008..87232	+	225	WP_159264233.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FMA36_RS17265	87233..87643	+	411	WP_159264234.1	tRNA(fMet)-specific endonuclease VapC	Toxin
FMA36_RS17270	88398..89234	-	837	WP_159264235.1	SDR family oxidoreductase	-
FMA36_RS17275	89287..90300	-	1014	WP_159264236.1	SDR family NAD(P)-dependent oxidoreductase	-
FMA36_RS17280	90395..91371	+	977	Protein_94	AraC family transcriptional regulator	-
FMA36_RS17285	91467..92390	-	924	WP_159264237.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..233861	233861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15365.64 Da
• Isoelectric Point: 7.7786

>T128126 WP_159264234.1 NZ_CP041349:87233-87643 [Komagataeibacter xylinus]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVEHFAARLAVLPFDSEAAAHT
ADIRAALERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEGWLTGTV

Nucleotide

• Length: 411 bp

>T128126 NZ_CP041349:87233-87643 [Komagataeibacter xylinus]
ATGCTGCGTTATCTGCTGGATACGAATCTCTGTATCCGGGTGTTGCGGGATCGACCACAAGGGCTGCGTCCGAGATTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAACTGCTTTATGGCGCGGAGCGCTCGTCTGATCCTG
TGCGCACCAGACGCGAGGTTGAGCACTTCGCGGCAAGGCTGGCAGTCCTGCCATTCGATAGTGAAGCGGCTGCCCATACA
GCGGATATTCGGGCTGCTCTTGAACGGAATGGCCGTATCATAGGTCCATATGATCTCATGATTGCCGGGCATGCCCGAAG
CAGGGGGCTGATTGTCGTGACGGGGAACCTTCGGGAATTCCAGCGGGTAGAGGGGCTTCGAACGGAGGGCTGGCTTACTG
GCACGGTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8265.45 Da
• Isoelectric Point: 4.9816

>AT128126 WP_159264233.1 NZ_CP041349:87008-87232 [Komagataeibacter xylinus]
MLTRTTLFMSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPTMQEREAL

Nucleotide

• Length: 225 bp

>AT128126 NZ_CP041349:87008-87232 [Komagataeibacter xylinus]
ATGCTGACCCGTACGACACTCTTTATGTCCAACCGCTCGCAGGCAGTGCGCCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATCGTGTCCGAAGGTTCACGGCGGATCATCGCACCGGCCGATGCAGCGTGGGATGATTTCTTTG
CGGCTCCCGGGGTGGATCTGGGGGAGCGAAACCAGCCGACCATGCAGGAACGCGAGGCGCTCTGA