Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 63761..64396 Replicon plasmid pA
Accession NZ_CP041349
Organism Komagataeibacter xylinus strain CGMCC 17276

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FMA36_RS17125 Protein ID WP_159264190.1
Coordinates 63986..64396 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FMA36_RS17120 Protein ID WP_159264188.1
Coordinates 63761..63985 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMA36_RS17105 60848..62098 + 1251 WP_159264185.1 hypothetical protein -
FMA36_RS17110 62095..62709 - 615 WP_010511769.1 hydroxyethylthiazole kinase -
FMA36_RS17115 63156..63581 - 426 WP_159264187.1 hypothetical protein -
FMA36_RS17120 63761..63985 + 225 WP_159264188.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FMA36_RS17125 63986..64396 + 411 WP_159264190.1 type II toxin-antitoxin system VapC family toxin Toxin
FMA36_RS17130 64994..65896 + 903 WP_159264192.1 type 1 glutamine amidotransferase domain-containing protein -
FMA36_RS17135 66097..66987 - 891 WP_159264194.1 NAD(P)H-binding protein -
FMA36_RS17140 67145..68071 + 927 WP_159264196.1 AraC family transcriptional regulator -
FMA36_RS17145 68290..69195 - 906 WP_159264197.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..233861 233861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15524.78 Da        Isoelectric Point: 6.7084

>T128125 WP_159264190.1 NZ_CP041349:63986-64396 [Komagataeibacter xylinus]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVEHFAVRLAVLPFDSEAAAHT
ADIRADLERNGRIIGPYDLMIAGHARSKGLIVVTGNLREFQRVEGLRTENWLTDTV

Download         Length: 411 bp

>T128125 NZ_CP041349:63986-64396 [Komagataeibacter xylinus]
ATGCTGCGTTATCTGCTGGATACGAACCTCTGTATCCGGGTGTTGCGGGATCGACCGCAGGGGTTGCGTCCGAGGTTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAACTGCTTTATGGCGCGGAACGCTCGTCTGATCCTG
TGCGCACAAGGCGTGAGGTCGAGCACTTCGCGGTAAGGCTGGCGGTCTTGCCATTCGACAGTGAAGCGGCCGCCCATACG
GCGGACATTCGGGCCGATCTTGAACGGAATGGGCGTATCATAGGTCCATATGATCTCATGATTGCCGGGCATGCCCGGAG
CAAAGGGCTGATTGTGGTGACCGGCAATCTGCGGGAATTTCAGCGGGTGGAGGGTCTTCGAACCGAAAACTGGCTGACTG
ACACGGTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8269.47 Da        Isoelectric Point: 7.0125

>AT128125 WP_159264188.1 NZ_CP041349:63761-63985 [Komagataeibacter xylinus]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVREVVIVSEGSRRIIAPADAARDDFFAAHGVDLGERNQPVMQEREAL

Download         Length: 225 bp

>AT128125 NZ_CP041349:63761-63985 [Komagataeibacter xylinus]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTACGTCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTACGCGAGGTGGTCATCGTGTCCGAAGGGTCTCGGCGGATCATCGCTCCGGCCGATGCGGCGCGGGATGATTTCTTTG
CGGCCCACGGGGTGGATCTGGGGGAGCGGAACCAGCCAGTCATGCAGGAACGCGAGGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References