Detailed information of TA system TA128124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3455890..3456440
• Replicon: chromosome
• Accession: NZ_CP041348
• Organism: Komagataeibacter xylinus strain CGMCC 17276

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: FMA36_RS16485
• Protein ID: WP_003618711.1
• Coordinates: 3455890..3456183 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: FMA36_RS16490
• Protein ID: WP_003618686.1
• Coordinates: 3456180..3456440 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FMA36_RS16465	3452193..3452762	-	570	WP_007400745.1	hydrolase	-
FMA36_RS16470	3452863..3453522	+	660	WP_040000214.1	TetR/AcrR family transcriptional regulator	-
FMA36_RS16475	3453813..3454496	-	684	WP_159263359.1	DUF1275 domain-containing protein	-
FMA36_RS16480	3454496..3455758	-	1263	WP_029604386.1	sodium:proton antiporter	-
FMA36_RS16485	3455890..3456183	-	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FMA36_RS16490	3456180..3456440	-	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FMA36_RS16495	3456609..3458795	-	2187	WP_040000208.1	ATP-dependent RecD-like DNA helicase	-
FMA36_RS16500	3459037..3459225	+	189	WP_083824344.1	hypothetical protein	-
FMA36_RS16505	3459239..3460918	+	1680	WP_159264080.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11605.35 Da
• Isoelectric Point: 7.9998

>T128124 WP_003618711.1 NZ_CP041348:c3456183-3455890 [Komagataeibacter xylinus]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Nucleotide

• Length: 294 bp

>T128124 NZ_CP041348:c3456183-3455890 [Komagataeibacter xylinus]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCACTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9762.23 Da
• Isoelectric Point: 10.4645

>AT128124 WP_003618686.1 NZ_CP041348:c3456440-3456180 [Komagataeibacter xylinus]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Nucleotide

• Length: 261 bp

>AT128124 NZ_CP041348:c3456440-3456180 [Komagataeibacter xylinus]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6