Detailed information of TA system TA128121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 219398..219948
• Replicon: chromosome
• Accession: NZ_CP041348
• Organism: Komagataeibacter xylinus strain CGMCC 17276

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: FMA36_RS01115
• Protein ID: WP_003618711.1
• Coordinates: 219655..219948 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: FMA36_RS01110
• Protein ID: WP_003618686.1
• Coordinates: 219398..219658 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FMA36_RS01085	214693..215721	+	1029	WP_003618826.1	methionine synthase	-
FMA36_RS01090	215880..216173	-	294	WP_003618825.1	hypothetical protein	-
FMA36_RS01095	216370..217032	-	663	WP_003618823.1	epoxyqueuosine reductase QueH	-
FMA36_RS01100	216944..218002	-	1059	WP_040510584.1	methylenetetrahydrofolate reductase [NAD(P)H]	-
FMA36_RS01105	218228..219127	+	900	WP_040510582.1	LysR family transcriptional regulator	-
FMA36_RS01110	219398..219658	+	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FMA36_RS01115	219655..219948	+	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FMA36_RS01120	220079..221341	+	1263	WP_159260229.1	sodium:proton antiporter	-
FMA36_RS01125	221341..222024	+	684	WP_003618716.1	DUF1275 domain-containing protein	-
FMA36_RS01130	222279..223352	+	1074	WP_003618718.1	alkene reductase	-
FMA36_RS01135	223553..223882	-	330	WP_003618720.1	endoribonuclease MazF	-
FMA36_RS01140	223883..224125	-	243	WP_003618721.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FMA36_RS01145	224260..224685	-	426	WP_003618781.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	174150..272209	98059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11605.35 Da
• Isoelectric Point: 7.9998

>T128121 WP_003618711.1 NZ_CP041348:219655-219948 [Komagataeibacter xylinus]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Nucleotide

• Length: 294 bp

>T128121 NZ_CP041348:219655-219948 [Komagataeibacter xylinus]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCGCTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9762.23 Da
• Isoelectric Point: 10.4645

>AT128121 WP_003618686.1 NZ_CP041348:219398-219658 [Komagataeibacter xylinus]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Nucleotide

• Length: 261 bp

>AT128121 NZ_CP041348:219398-219658 [Komagataeibacter xylinus]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6