Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 569912..570945 Replicon chromosome
Accession NZ_CP041344
Organism Enterococcus faecalis strain DM01

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag FLL49_RS03010 Protein ID WP_141893160.1
Coordinates 569912..570565 (-) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag FLL49_RS03015 Protein ID WP_002394275.1
Coordinates 570562..570945 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLL49_RS02980 565942..566142 + 201 Protein_532 cold-shock protein -
FLL49_RS02985 566234..566461 + 228 WP_016626396.1 hypothetical protein -
FLL49_RS02990 566714..567763 + 1050 WP_141893156.1 hypothetical protein -
FLL49_RS02995 567808..568071 + 264 Protein_535 aldo/keto reductase -
FLL49_RS03000 568170..569501 + 1332 WP_141893158.1 FAD-dependent oxidoreductase -
FLL49_RS03005 569539..569874 - 336 WP_016626325.1 helix-turn-helix transcriptional regulator -
FLL49_RS03010 569912..570565 - 654 WP_141893160.1 ImmA/IrrE family metallo-endopeptidase Toxin
FLL49_RS03015 570562..570945 - 384 WP_002394275.1 helix-turn-helix transcriptional regulator Antitoxin
FLL49_RS03020 571691..571942 + 252 WP_002365227.1 hypothetical protein -
FLL49_RS03025 572028..572354 + 327 WP_141893162.1 hypothetical protein -
FLL49_RS03030 572354..572770 + 417 WP_002380876.1 DUF961 family protein -
FLL49_RS03035 572942..573130 - 189 WP_002394271.1 hypothetical protein -
FLL49_RS03040 573357..573509 + 153 WP_016626387.1 hypothetical protein -
FLL49_RS03045 573551..573844 + 294 WP_029736788.1 hypothetical protein -
FLL49_RS03050 573904..574230 + 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
FLL49_RS03055 574220..574600 + 381 WP_002402315.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26061.00 Da        Isoelectric Point: 6.2394

>T128094 WP_141893160.1 NZ_CP041344:c570565-569912 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEIMHYYIDIPKINNATHTFSDILLKNGYLIEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

>T128094 NZ_CP041344:c570565-569912 [Enterococcus faecalis]
TTGATTGGACTGTTGTTGGTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAA
AGAAGTATCTTACTACTCTTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAG
ATGTTGAATTTGTTGAATACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAA
GTCATTATAACAACAAACAAGGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGATTATGCATTACTACAT
AGATATACCTAAAATTAATAATGCAACCCATACTTTTTCTGATATTCTTTTGAAAAATGGTTATTTGATAGAAGATTTTC
CAAAAGAATATCGTGCTAATGTCGGTGCTAGCATGTTAATGGCAAATGACCAAGCATTGTTTTACGCATTAAAAAAATTT
TATTCATTCGAAGAAATTGCACAATACTTTTTTATGAGCAAATCTGCATTAAGAAATAGACTCATCGAACATCTTATGTA
TGTAAATAACTGTACTTTTGCACACGCTAATACACTTTTTAACAATTATTACTTTCATAAAGAAACTGACATCTACAGAT
TTATTTTCAATTAG

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 15033.02 Da        Isoelectric Point: 4.9352

>AT128094 WP_002394275.1 NZ_CP041344:c570945-570562 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 384 bp

>AT128094 NZ_CP041344:c570945-570562 [Enterococcus faecalis]
GTGCAACCATTAGCAAAAAGACTACAGCTTTTAAGAGAAGAAAAAGAATGGACAAAAACATATGTTGCAAAACAACTAGG
CTTAAATAACTTAGGAACCTATGCAAACTGGGAATATGGAACACGTGAACCAGATTCGGAAATGCTATCAAAAATTGCTT
CCTTATATGATGTATCTACCGATTTTTTACTAGGTAGAACAGAGGAAAGAATACATCTAAACGACAAGGAAAAAATTGGA
AAAAATATCATTTCTCATTTTCGTTTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAGGAATTAAT
CGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References