Detailed information of TA system TA128068

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3045795..3046615
• Replicon: chromosome
• Accession: NZ_CP041337
• Organism: Escherichia coli strain CCUG 73778

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: FMA85_RS14970
• Protein ID: WP_001054379.1
• Coordinates: 3045795..3046052 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: FMA85_RS14975
• Protein ID: WP_000123957.1
• Coordinates: 3046064..3046615 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FMA85_RS14950	3041342..3042322	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
FMA85_RS14955	3042905..3043948	-	1044	WP_001363826.1	hypothetical protein	-
FMA85_RS14960	3044074..3045221	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
FMA85_RS14965	3045254..3045418	+	165	Protein_2940	GNAT family N-acetyltransferase	-
FMA85_RS14970	3045795..3046052	+	258	WP_001054379.1	YjhX family toxin	Toxin
FMA85_RS14975	3046064..3046615	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
FMA85_RS14980	3046667..3047413	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
FMA85_RS14985	3047541..3047801	+	261	WP_000077645.1	hypothetical protein	-
FMA85_RS26255	3047839..3047955	+	117	Protein_2945	VOC family protein	-
FMA85_RS14990	3048200..3049321	+	1122	WP_000010833.1	M42 family metallopeptidase	-
FMA85_RS14995	3049318..3049596	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
FMA85_RS15000	3049608..3050921	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T128068 WP_001054379.1 NZ_CP041337:3045795-3046052 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T128068 NZ_CP041337:3045795-3046052 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT128068 WP_000123957.1 NZ_CP041337:3046064-3046615 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT128068 NZ_CP041337:3046064-3046615 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030