Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2217335..2218890 Replicon chromosome
Accession NZ_CP041334
Organism Glaesserella parasuis strain HPS412

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FLK62_RS11240 Protein ID WP_160413780.1
Coordinates 2217335..2218657 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag FLK62_RS11245 Protein ID WP_010786623.1
Coordinates 2218651..2218890 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLK62_RS11200 2212554..2213141 + 588 WP_010787333.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
FLK62_RS11205 2213397..2213576 - 180 Protein_2162 disulfide bond formation protein DsbA -
FLK62_RS11210 2213576..2214019 - 444 WP_005713602.1 nuclear transport factor 2 family protein -
FLK62_RS11215 2214154..2214270 + 117 Protein_2164 LysR family transcriptional regulator -
FLK62_RS11220 2214351..2214924 - 574 Protein_2165 virulence RhuM family protein -
FLK62_RS11225 2215111..2215470 - 360 WP_010787368.1 hypothetical protein -
FLK62_RS11230 2215587..2215772 + 186 WP_149351189.1 hypothetical protein -
FLK62_RS11235 2216084..2217331 + 1248 Protein_2168 PLP-dependent aminotransferase family protein -
FLK62_RS11240 2217335..2218657 - 1323 WP_160413780.1 HipA domain-containing protein Toxin
FLK62_RS11245 2218651..2218890 - 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
FLK62_RS11250 2219038..2219865 - 828 WP_160428948.1 alpha/beta hydrolase -
FLK62_RS11255 2219996..2221441 + 1446 WP_035491668.1 metalloprotease TldD -
FLK62_RS11260 2221696..2222106 + 411 WP_005713295.1 preprotein translocase subunit SecE -
FLK62_RS11265 2222108..2222686 + 579 WP_005713298.1 transcription termination/antitermination protein NusG -
FLK62_RS11270 2222812..2223369 - 558 WP_020457615.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50185.46 Da        Isoelectric Point: 7.3465

>T128051 WP_160413780.1 NZ_CP041334:c2218657-2217335 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSL
AIEKQGRYHLSPVYDVISAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQIC
DTVQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1323 bp

>T128051 NZ_CP041334:c2218657-2217335 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCCTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAGACGAAAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAAGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACG
ATCGCCGTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTC
GCCATTGAAAAACAAGGGCGTTATCACTTATCCCCTGTGTATGACGTAATTTCTGCTTATCCAATGTTAGGAGGAAAAGG
TTGGCATCACAGCGAATTGCAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTT
ACGCTGAACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGC
GATACAGTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATT
CACGGGCATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT128051 WP_010786623.1 NZ_CP041334:c2218890-2218651 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT128051 NZ_CP041334:c2218890-2218651 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References