Detailed information of TA system TA128050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1865939..1866478
• Replicon: chromosome
• Accession: NZ_CP041334
• Organism: Glaesserella parasuis strain HPS412

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6I5WQI8
• Locus tag: FLK62_RS09350
• Protein ID: WP_005714578.1
• Coordinates: 1865939..1866208 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FLK62_RS09355
• Protein ID: WP_176443842.1
• Coordinates: 1866212..1866478 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLK62_RS09335	1863788..1864063	-	276	WP_149351071.1	hypothetical protein	-
FLK62_RS09340	1864266..1864529	-	264	WP_165549647.1	hypothetical protein	-
FLK62_RS09345	1864585..1865793	+	1209	WP_149350925.1	IS256 family transposase	-
FLK62_RS09350	1865939..1866208	-	270	WP_005714578.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FLK62_RS09355	1866212..1866478	-	267	WP_176443842.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FLK62_RS09360	1866547..1866774	-	228	WP_005714573.1	DUF4035 domain-containing protein	-
FLK62_RS09365	1866819..1867220	-	402	WP_176443843.1	hypothetical protein	-
FLK62_RS09370	1867294..1867959	-	666	WP_176443844.1	hypothetical protein	-
FLK62_RS09375	1867962..1868381	-	420	WP_005714567.1	phage tail protein	-
FLK62_RS09380	1868381..1868914	-	534	WP_176443845.1	phage tail protein	-
FLK62_RS09385	1868918..1869220	-	303	WP_012621828.1	phage tail protein	-
FLK62_RS09390	1869213..1869539	-	327	WP_010786318.1	DUF2190 family protein	-
FLK62_RS09395	1869597..1870583	-	987	WP_005714908.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1852491..1880768	28277
	-	flank	IS/Tn	-	-	1864585..1865793	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-83)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.03 Da
• Isoelectric Point: 6.8591

>T128050 WP_005714578.1 NZ_CP041334:c1866208-1865939 [Glaesserella parasuis]
MLQLSPTNAYKRDFKKIASELMSSAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Nucleotide

• Length: 270 bp

>T128050 NZ_CP041334:c1866208-1865939 [Glaesserella parasuis]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGTCTAGTGCTGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9944.40 Da
• Isoelectric Point: 5.7855

>AT128050 WP_176443842.1 NZ_CP041334:c1866478-1866212 [Glaesserella parasuis]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNQVYESLEA
FHKAMLAE

Nucleotide

• Length: 267 bp

>AT128050 NZ_CP041334:c1866478-1866212 [Glaesserella parasuis]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAGACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAAAATCAAGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A6I5WQI8