Detailed information of TA system TA128047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1243811..1244588
• Replicon: chromosome
• Accession: NZ_CP041334
• Organism: Glaesserella parasuis strain HPS412

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: FLK62_RS06145
• Protein ID: WP_021118351.1
• Coordinates: 1243811..1244311 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: FLK62_RS06150
• Protein ID: WP_005710653.1
• Coordinates: 1244301..1244588 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLK62_RS06110	1238937..1239092	-	156	WP_005710668.1	YoaH family protein	-
FLK62_RS06115	1239110..1239838	-	729	WP_021115014.1	tRNA pseudouridine(65) synthase TruC	-
FLK62_RS06120	1239835..1240149	-	315	WP_005710664.1	YqcC family protein	-
FLK62_RS06125	1240191..1241105	-	915	WP_176443642.1	N-acetylmuramic acid 6-phosphate etherase	-
FLK62_RS06130	1241117..1242232	-	1116	WP_176443643.1	anhydro-N-acetylmuramic acid kinase	-
FLK62_RS06135	1242386..1242721	-	336	WP_016527793.1	outer membrane protein assembly factor BamE	-
FLK62_RS06140	1242782..1243783	-	1002	WP_176443644.1	nucleoid-associated protein YejK	-
FLK62_RS06145	1243811..1244311	-	501	WP_021118351.1	GNAT family N-acetyltransferase	Toxin
FLK62_RS06150	1244301..1244588	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
FLK62_RS06155	1244734..1245123	+	390	WP_160421809.1	RidA family protein	-
FLK62_RS06160	1245127..1245864	+	738	WP_038513738.1	peptidoglycan editing factor PgeF	-
FLK62_RS06165	1246039..1247616	+	1578	WP_005710646.1	FAD-binding protein	-
FLK62_RS06170	1247720..1248220	+	501	WP_176443998.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19097.26 Da
• Isoelectric Point: 9.2835

>T128047 WP_021118351.1 NZ_CP041334:c1244311-1243811 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYSRQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T128047 NZ_CP041334:c1244311-1243811 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACTCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT128047 WP_005710653.1 NZ_CP041334:c1244588-1244301 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT128047 NZ_CP041334:c1244588-1244301 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTCACCCATACGAATATTACAGAATTTGTATTACAACGCATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: U4SPD7