Detailed information of TA system TA128046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-stbD/ParE-DnaT
• Location: 756653..757188
• Replicon: chromosome
• Accession: NZ_CP041334
• Organism: Glaesserella parasuis strain HPS412

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FLK62_RS03740
• Protein ID: WP_176443534.1
• Coordinates: 756904..757188 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A836Z1U9
• Locus tag: FLK62_RS03735
• Protein ID: WP_010785924.1
• Coordinates: 756653..756907 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLK62_RS03715	752231..752773	+	543	WP_005712695.1	adenine phosphoribosyltransferase	-
FLK62_RS03720	752838..754856	+	2019	WP_176443533.1	DNA polymerase III subunit gamma/tau	-
FLK62_RS03725	754862..755758	+	897	WP_021110407.1	ABC transporter ATP-binding protein	-
FLK62_RS03730	755780..756535	+	756	WP_012621503.1	ABC transporter permease	-
FLK62_RS03735	756653..756907	+	255	WP_010785924.1	plasmid stability protein StbD	Antitoxin
FLK62_RS03740	756904..757188	+	285	WP_176443534.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FLK62_RS03745	757397..758947	+	1551	WP_176443535.1	exodeoxyribonuclease I	-
FLK62_RS03750	759030..759989	+	960	WP_176443536.1	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	-
FLK62_RS03755	760024..760620	+	597	WP_020996918.1	uracil DNA glycosylase superfamily protein	-
FLK62_RS03760	760621..761442	+	822	WP_112063032.1	PHP domain-containing protein	-
FLK62_RS03765	761548..762039	-	492	WP_160402719.1	acetolactate synthase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11261.30 Da
• Isoelectric Point: 10.5362

>T128046 WP_176443534.1 NZ_CP041334:756904-757188 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKVQLRL

Nucleotide

• Length: 285 bp

>T128046 NZ_CP041334:756904-757188 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTATATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACTGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9333.70 Da
• Isoelectric Point: 4.4131

>AT128046 WP_010785924.1 NZ_CP041334:756653-756907 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Nucleotide

• Length: 255 bp

>AT128046 NZ_CP041334:756653-756907 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A836Z1U9