Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 588439..589019 Replicon chromosome
Accession NZ_CP041334
Organism Glaesserella parasuis strain HPS412

Toxin (Protein)


Gene name mazF Uniprot ID A0A836MFL2
Locus tag FLK62_RS02905 Protein ID WP_021114594.1
Coordinates 588675..589019 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag FLK62_RS02900 Protein ID WP_005710601.1
Coordinates 588439..588678 (+) Length 80 a.a.

Genomic Context


FLK62_RS02900FLK62_RS02905FLK62_RS02910FLK62_RS02915FLK62_RS02875FLK62_RS02880FLK62_RS02885FLK62_RS02890FLK62_RS02895FLK62_RS02920FLK62_RS02925
Location: 588439..588678 (240 bp)
Type: Antitoxin
Protein ID: WP_005710601.1
Location: 588675..589019 (345 bp)
Type: Toxin
Protein ID: WP_021114594.1
Location: 589025..589693 (669 bp)
Type: Others
Protein ID: WP_176443469.1
Location: 589706..591097 (1392 bp)
Type: Others
Protein ID: WP_160433564.1
Location: 584143..584835 (693 bp)
Type: Others
Protein ID: WP_010785974.1
Location: 584897..585745 (849 bp)
Type: Others
Protein ID: WP_149350759.1
Location: 585742..586527 (786 bp)
Type: Others
Protein ID: WP_176443467.1
Location: 586517..587269 (753 bp)
Type: Others
Protein ID: WP_102033221.1
Location: 587378..588253 (876 bp)
Type: Others
Protein ID: WP_176443468.1
Location: 591170..593275 (2106 bp)
Type: Others
Protein ID: WP_176443470.1
Location: 593481..593777 (297 bp)
Type: Others
Protein ID: WP_005710591.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FLK62_RS02875584143..584835-693WP_010785974.1tellurite resistance TerB family protein-
FLK62_RS02880584897..585745-849WP_149350759.1ABC transporter permease subunit-
FLK62_RS02885585742..586527-786WP_176443467.1ABC transporter permease subunit-
FLK62_RS02890586517..587269-753WP_102033221.1phosphonate ABC transporter ATP-binding protein-
FLK62_RS02895587378..588253-876WP_176443468.1putative selenate ABC transporter substrate-binding protein-
FLK62_RS02900588439..588678+240WP_005710601.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FLK62_RS02905588675..589019+345WP_021114594.1endoribonuclease MazFToxin
FLK62_RS02910589025..589693+669WP_176443469.1bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA-
FLK62_RS02915589706..591097+1392WP_160433564.1MATE family efflux transporter-
FLK62_RS02920591170..593275-2106WP_176443470.1hypothetical protein-
FLK62_RS02925593481..593777-297WP_005710591.1DUF5374 domain-containing protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-111)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 12801.77 Da        Isoelectric Point: 7.3830

>T128045 WP_021114594.1 NZ_CP041334:588675-589019 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVDIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

>T128045 NZ_CP041334:588675-589019 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCGCGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTTGAAGTCGATATTGCAGGTACCCCTCAAAATGTTGTACTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT128045 WP_005710601.1 NZ_CP041334:588439-588678 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp

>AT128045 NZ_CP041334:588439-588678 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGCATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A836MFL2


Antitoxin

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Source
ID
Structure
AlphaFold DBU4SAI4

References