Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 588439..589019 | Replicon | chromosome |
Accession | NZ_CP041334 | ||
Organism | Glaesserella parasuis strain HPS412 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A836MFL2 |
Locus tag | FLK62_RS02905 | Protein ID | WP_021114594.1 |
Coordinates | 588675..589019 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | U4SAI4 |
Locus tag | FLK62_RS02900 | Protein ID | WP_005710601.1 |
Coordinates | 588439..588678 (+) | Length | 80 a.a. |
Genomic Context
Location: 588439..588678 (240 bp)
Type: Antitoxin
Protein ID: WP_005710601.1
Type: Antitoxin
Protein ID: WP_005710601.1
Location: 588675..589019 (345 bp)
Type: Toxin
Protein ID: WP_021114594.1
Type: Toxin
Protein ID: WP_021114594.1
Location: 589025..589693 (669 bp)
Type: Others
Protein ID: WP_176443469.1
Type: Others
Protein ID: WP_176443469.1
Location: 589706..591097 (1392 bp)
Type: Others
Protein ID: WP_160433564.1
Type: Others
Protein ID: WP_160433564.1
Location: 584143..584835 (693 bp)
Type: Others
Protein ID: WP_010785974.1
Type: Others
Protein ID: WP_010785974.1
Location: 584897..585745 (849 bp)
Type: Others
Protein ID: WP_149350759.1
Type: Others
Protein ID: WP_149350759.1
Location: 585742..586527 (786 bp)
Type: Others
Protein ID: WP_176443467.1
Type: Others
Protein ID: WP_176443467.1
Location: 586517..587269 (753 bp)
Type: Others
Protein ID: WP_102033221.1
Type: Others
Protein ID: WP_102033221.1
Location: 587378..588253 (876 bp)
Type: Others
Protein ID: WP_176443468.1
Type: Others
Protein ID: WP_176443468.1
Location: 591170..593275 (2106 bp)
Type: Others
Protein ID: WP_176443470.1
Type: Others
Protein ID: WP_176443470.1
Location: 593481..593777 (297 bp)
Type: Others
Protein ID: WP_005710591.1
Type: Others
Protein ID: WP_005710591.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FLK62_RS02875 | 584143..584835 | - | 693 | WP_010785974.1 | tellurite resistance TerB family protein | - |
FLK62_RS02880 | 584897..585745 | - | 849 | WP_149350759.1 | ABC transporter permease subunit | - |
FLK62_RS02885 | 585742..586527 | - | 786 | WP_176443467.1 | ABC transporter permease subunit | - |
FLK62_RS02890 | 586517..587269 | - | 753 | WP_102033221.1 | phosphonate ABC transporter ATP-binding protein | - |
FLK62_RS02895 | 587378..588253 | - | 876 | WP_176443468.1 | putative selenate ABC transporter substrate-binding protein | - |
FLK62_RS02900 | 588439..588678 | + | 240 | WP_005710601.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
FLK62_RS02905 | 588675..589019 | + | 345 | WP_021114594.1 | endoribonuclease MazF | Toxin |
FLK62_RS02910 | 589025..589693 | + | 669 | WP_176443469.1 | bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA | - |
FLK62_RS02915 | 589706..591097 | + | 1392 | WP_160433564.1 | MATE family efflux transporter | - |
FLK62_RS02920 | 591170..593275 | - | 2106 | WP_176443470.1 | hypothetical protein | - |
FLK62_RS02925 | 593481..593777 | - | 297 | WP_005710591.1 | DUF5374 domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12801.77 Da Isoelectric Point: 7.3830
>T128045 WP_021114594.1 NZ_CP041334:588675-589019 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVDIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVDIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE
Download Length: 345 bp
>T128045 NZ_CP041334:588675-589019 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCGCGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTTGAAGTCGATATTGCAGGTACCCCTCAAAATGTTGTACTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCGCGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTTGAAGTCGATATTGCAGGTACCCCTCAAAATGTTGTACTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8782.21 Da Isoelectric Point: 5.0351
>AT128045 WP_005710601.1 NZ_CP041334:588439-588678 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML
Download Length: 240 bp
>AT128045 NZ_CP041334:588439-588678 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGCATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGCATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A836MFL2 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | U4SAI4 |