Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4437437..4438272 Replicon chromosome
Accession NZ_CP041304
Organism Escherichia coli strain MSHS 133

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FK544_RS23105 Protein ID WP_141841291.1
Coordinates 4437895..4438272 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag FK544_RS23100 Protein ID WP_001285607.1
Coordinates 4437437..4437805 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FK544_RS23065 4433329..4434009 + 681 WP_001282919.1 WYL domain-containing protein -
FK544_RS23070 4434157..4434834 + 678 WP_001097301.1 hypothetical protein -
FK544_RS23075 4434840..4435073 + 234 WP_001278287.1 DUF905 family protein -
FK544_RS23080 4435163..4435981 + 819 WP_001175163.1 DUF945 domain-containing protein -
FK544_RS23085 4436073..4436558 + 486 WP_000206664.1 antirestriction protein -
FK544_RS23090 4436573..4437049 + 477 WP_001186165.1 RadC family protein -
FK544_RS23095 4437136..4437357 + 222 WP_000692350.1 DUF987 domain-containing protein -
FK544_RS23100 4437437..4437805 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FK544_RS23105 4437895..4438272 + 378 WP_141841291.1 TA system toxin CbtA family protein Toxin
FK544_RS23110 4438269..4438757 + 489 WP_001774608.1 hypothetical protein -
FK544_RS23115 4438769..4438966 + 198 WP_032152719.1 DUF957 domain-containing protein -
FK544_RS23120 4439051..4439893 + 843 WP_032152755.1 DUF4942 domain-containing protein -
FK544_RS23130 4440642..4442180 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14204.13 Da        Isoelectric Point: 7.2920

>T128040 WP_141841291.1 NZ_CP041304:4437895-4438272 [Escherichia coli]
MNTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T128040 NZ_CP041304:4437895-4438272 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT128040 WP_001285607.1 NZ_CP041304:4437437-4437805 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT128040 NZ_CP041304:4437437-4437805 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References