Detailed information of TA system TA127937

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2556729..2557353
• Replicon: chromosome
• Accession: NZ_CP041295
• Organism: Acinetobacter indicus strain 80-1-2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9KY14
• Locus tag: FK538_RS12220
• Protein ID: WP_005180237.1
• Coordinates: 2556729..2557121 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FK538_RS12225
• Protein ID: WP_171065118.1
• Coordinates: 2557108..2557353 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FK538_RS12205	2552054..2554330	-	2277	WP_168370735.1	TRAP transporter large permease subunit	-
FK538_RS12210	2554511..2555083	-	573	WP_104503628.1	rhombosortase	-
FK538_RS12215	2555139..2556212	-	1074	WP_045795327.1	hypothetical protein	-
FK538_RS12220	2556729..2557121	-	393	WP_005180237.1	hypothetical protein	Toxin
FK538_RS12225	2557108..2557353	-	246	WP_171065118.1	succinate dehydrogenase assembly factor 2	Antitoxin
FK538_RS12230	2557549..2558721	+	1173	WP_168370736.1	acyl-CoA dehydrogenase family protein	-
FK538_RS12235	2558809..2560299	-	1491	WP_104473156.1	NAD(P)/FAD-dependent oxidoreductase	-
FK538_RS12240	2560496..2560861	-	366	WP_004754212.1	50S ribosomal protein L17	-
FK538_RS12245	2560881..2561888	-	1008	WP_005180245.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14930.64 Da
• Isoelectric Point: 10.4540

>T127937 WP_005180237.1 NZ_CP041295:c2557121-2556729 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Nucleotide

• Length: 393 bp

>T127937 NZ_CP041295:c2557121-2556729 [Acinetobacter indicus]
ATGTCCACGGCTAAGCGCGACTTTCAGCTGAAACCGAGCCGTCTGGCGCTGCTGTTTCAGCTGAGCCTGCTGATTCTATT
TTCTGTTTTAAGTTTTCAATTATTACATCCGCTGCTTTGGCTGCTAGGTCTGCTCCTGGCGGCTGTCAGTTATTACGGGT
TTCAGCGACGCTCCCAATTAACCGCCTTGGCGCATTTAGATGGGGCAGAGTGGAGTCTGCAGTTTAATTCTGGCTCCAAG
ATTCAACGCGGTCTGCTCGAGCATATTCTGGATCATCAGCTGTATCTGGTGCTGTATTTTCATCATGCACCGGTCAAATC
TGCAGTCATCTGGCGTGACCAAGTTTCGTTTGCAGAGTGGAAAGCCTTAAAAACATTGGCAAAAACCATCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9758.15 Da
• Isoelectric Point: 4.9108

>AT127937 WP_171065118.1 NZ_CP041295:c2557353-2557108 [Acinetobacter indicus]
ISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT127937 NZ_CP041295:c2557353-2557108 [Acinetobacter indicus]
ATTAGCTTAGAAGAGCGTAAAGTGATTTATCGTGCCCGTCGCGGTTTAAAGGAAATTGATGTCTACTTTGATCCTTATGT
AAAAAACTATTATTTAACCGCTGATCCGGAAGAAAAAGCCACGTTTGCTGCGCTGGTTGAACAGGAAGATCCGGATTTAC
TGGACTGGTTTATGGAAGTGTCTGAACCGCCACGCCCGGAAATGCGCGAGCTGATCCGTAAATTAAAACACTATGTCCAC
GGCTAA

Structures

Toxin

• AlphaFold DB: N9KY14