Detailed information of TA system TA127936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1460890..1462005
• Replicon: chromosome
• Accession: NZ_CP041295
• Organism: Acinetobacter indicus strain 80-1-2

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: FK538_RS07100
• Protein ID: WP_016658124.1
• Coordinates: 1461841..1462005 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: FK538_RS07095
• Protein ID: WP_104473131.1
• Coordinates: 1460890..1461759 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FK538_RS07075	1456987..1457436	+	450	WP_104473134.1	cyanase	-
FK538_RS07080	1457626..1458210	-	585	WP_168370511.1	KGG domain-containing protein	-
FK538_RS07085	1458648..1459889	-	1242	WP_168370512.1	MFS transporter	-
FK538_RS07090	1460548..1460787	+	240	WP_104471337.1	DUF2171 domain-containing protein	-
FK538_RS07095	1460890..1461759	+	870	WP_104473131.1	SDR family oxidoreductase	Antitoxin
FK538_RS07100	1461841..1462005	+	165	WP_016658124.1	hypothetical protein	Toxin
FK538_RS07105	1462105..1463523	-	1419	WP_104488883.1	iron-containing redox enzyme family protein	-
FK538_RS07110	1463824..1464981	-	1158	WP_171526197.1	fatty acid desaturase	-
FK538_RS07115	1465005..1466027	-	1023	WP_075166613.1	ferredoxin reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T127936 WP_016658124.1 NZ_CP041295:1461841-1462005 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T127936 NZ_CP041295:1461841-1462005 [Acinetobacter indicus]
ATGTCTAGAGGTGATAAGTCGGCCTATACCGACAAGCAGAAACGTCAGGCCCGCCATATTATTGAATCGGAAAAAGAGCG
AGGCCATTCCGAAGAAGAAGCAGAACGCATTGGCTGGTCTACCGTCAATAAACAGGATGGCGGCGGTAAAAAGAAATCTC
ACTAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31906.00 Da
• Isoelectric Point: 4.7484

>AT127936 WP_104473131.1 NZ_CP041295:1460890-1461759 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLYKTFETNLYPLFYV
TQLLIPQMQAGDSIINTTSITSYQGHNELIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT127936 NZ_CP041295:1460890-1461759 [Acinetobacter indicus]
ATGAATCATTATCCTGACAGCCCATCTCCGCAAGAGAAACAGGAGCATCAGCCTGGTGTACAATATAAAATGACGCCCGA
ACCTGAAATTATTAAAAGCAATTATCAGGGCAGTCAAAAACTCAAAGACAAGGTGGCTTTAATTACCGGCGGTGACAGCG
GCATCGGCCGATCTGTGGCGGTGCTGTTTGCCCGCGAAGGTGCCAATATTATTATTCCCTATTTAGAAGAAGATCAGGAT
GCGCAAGACACCAAGCGACTGGTTGAGCAGGAAGGTCGTCAATGTCTGCTGATTCAGTGTGACCTGCGCCAACATGCGGC
AGTGCAGCAGATGGTCGATCTGGCTTTGCAGCAGTTTCCGCATATTAATATTCTGGTCAATAATGCTGCTGTGCAATATC
CACAAAAAACCATTGAAGATATTAATCCCGAACAGCTGTATAAAACCTTTGAAACCAACCTCTACCCGCTGTTTTATGTG
ACCCAGCTGCTGATTCCTCAAATGCAGGCCGGTGACAGTATTATCAATACCACCAGTATCACCAGCTATCAGGGCCATAA
TGAGCTGATTGATTATGCCAGCACCAAAGGGGCAATTACCGCTTTTACCCGTAGCCTGTCGACCAACTTGCTGAAAAATA
AAACCGGGATTCGGGTGAATGGTGTCGCACCCGGCCCAATCTGGACGCCGTTAATTCCAAGCAGTTTTGATGAAGAACAG
CTAAAAGGTTTTGGTGAAGATACCCCCATGGGCCGCATGGGTCAGCCAAGTGAAGTTGCGCCGGCTTATCTGTTTTTAGC
CTCCGATGAAGCCAGCTATATTTCCGGTCAGGTGATTCATGTTAATGGCGGTACTATTGTCAATGGTTAA

Structures

Toxin

• AlphaFold DB: V2U6R6