Detailed information of TA system TA127891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 266842..267743
• Replicon: plasmid unnamed1
• Accession: NZ_CP041248
• Organism: Raoultella electrica strain DSM 102253

Toxin (Protein)

• Gene name: -
• Uniprot ID: S1EZ83
• Locus tag: Electrica_RS26785
• Protein ID: WP_008786589.1
• Coordinates: 266842..267300 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: Electrica_RS26790
• Protein ID: WP_008786588.1
• Coordinates: 267297..267743 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Electrica_RS26740	262568..262810	+	243	WP_007372291.1	hypothetical protein	-
Electrica_RS26745	262821..263219	+	399	WP_007372292.1	hypothetical protein	-
Electrica_RS26750	263303..263629	+	327	WP_142255944.1	hypothetical protein	-
Electrica_RS26755	263992..264330	-	339	WP_007372294.1	hypothetical protein	-
Electrica_RS26760	264568..265011	+	444	WP_007372295.1	hypothetical protein	-
Electrica_RS26765	265130..265471	+	342	WP_007372296.1	hypothetical protein	-
Electrica_RS26770	265630..266184	+	555	WP_007372297.1	hypothetical protein	-
Electrica_RS26775	266234..266500	+	267	WP_007372298.1	hypothetical protein	-
Electrica_RS26780	266568..266798	-	231	WP_007372299.1	hypothetical protein	-
Electrica_RS26785	266842..267300	-	459	WP_008786589.1	RES family NAD+ phosphorylase	Toxin
Electrica_RS26790	267297..267743	-	447	WP_008786588.1	DUF2384 domain-containing protein	Antitoxin
Electrica_RS26795	267892..268209	+	318	WP_016241555.1	hypothetical protein	-
Electrica_RS26800	268251..269093	+	843	WP_007372303.1	hypothetical protein	-
Electrica_RS26805	269065..269343	+	279	WP_007372304.1	hypothetical protein	-
Electrica_RS26810	269403..269846	+	444	WP_007372305.1	hypothetical protein	-
Electrica_RS28535	270133..270297	+	165	WP_007372306.1	hypothetical protein	-
Electrica_RS26815	270865..271707	+	843	WP_007372307.1	HNH endonuclease	-
Electrica_RS26820	272129..272380	+	252	WP_024196080.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..303830	303830

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17005.43 Da
• Isoelectric Point: 4.5730

>T127891 WP_008786589.1 NZ_CP041248:c267300-266842 [Raoultella electrica]
VILYRLTKTRYLMTAWSGLGAKETGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Nucleotide

• Length: 459 bp

>T127891 NZ_CP041248:c267300-266842 [Raoultella electrica]
GTGATCCTTTACCGACTGACCAAGACCCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCGAAAGAAACGGGGGGCCG
CTGGAACAGCGTAGGCACTGCAATGGTCTACCTGTCTGAAACGGCCAGCCTTACCATGCTTGAAACGCTGGTACACATTC
ACGCGCCGCAGTTACTGGACGACTTTACACTGCTGAGTCTTGATGTACCGGATGATCAGATCCAGACCTTCGACATGAGC
CGTCTCCCTGATAACTGGGCGAGTGAGGATGCTCCTGCTGAGCTGGCGCTCTACGGTGATAACTGGGCTGAAAGCGGTTC
TTCTATCGCGCTGCGTATTCCAAGTGCGTTGTCTCCGGTTGAATTTAACTACTTGCTGAATCCGGCACACCCTGAACTCT
TTGACCTGATGGCTACGGTTAAGAAAATTCCGTTCCGGTTTGATTCCCGCCTGAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16689.02 Da
• Isoelectric Point: 6.9812

>AT127891 WP_008786588.1 NZ_CP041248:c267743-267297 [Raoultella electrica]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Nucleotide

• Length: 447 bp

>AT127891 NZ_CP041248:c267743-267297 [Raoultella electrica]
ATGACGATGAAAGTTTTTTCTCCAGACGTTACCAAAACGAATCAGCACTGCTTATGGCAGGTTGCTGGGCTGGATAATGA
CGGTATCGCGCTGATGGATAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCTGAATGGGCTAACATCA
CGCCGTCTGAGCTGCGCAAAATGTCGGGTATACCTAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGAT
CAGAGCGAACGTCTGGTGCGCATTATCCGCGTAATTGAACGCGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCGGCGCA
CAAATGGCTGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGCTTGTTTCTTCTGAGACAGGTGCGCTTG
AAGTGATGCGCCTGATTACGCGTATTGAGCACGGGGTATACTCGTGA

Structures

Toxin

• AlphaFold DB: S1EZ83