Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4017603..4018222 Replicon chromosome
Accession NZ_CP041247
Organism Raoultella electrica strain DSM 102253

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag Electrica_RS19220 Protein ID WP_004858783.1
Coordinates 4018004..4018222 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag Electrica_RS19215 Protein ID WP_004858785.1
Coordinates 4017603..4017977 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Electrica_RS19205 4012715..4013908 + 1194 WP_100683172.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
Electrica_RS19210 4013931..4017077 + 3147 WP_141965201.1 multidrug efflux RND transporter permease subunit AcrB -
Electrica_RS19215 4017603..4017977 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
Electrica_RS19220 4018004..4018222 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
Electrica_RS19225 4018374..4018940 + 567 WP_100683170.1 maltose O-acetyltransferase -
Electrica_RS19230 4019040..4019510 + 471 WP_100683169.1 hypothetical protein -
Electrica_RS19235 4019485..4020930 - 1446 WP_141965202.1 PLP-dependent aminotransferase family protein -
Electrica_RS19240 4021041..4021751 + 711 WP_141965203.1 GNAT family N-acetyltransferase -
Electrica_RS19245 4021748..4021888 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
Electrica_RS19250 4021891..4022151 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T127888 WP_004858783.1 NZ_CP041247:4018004-4018222 [Raoultella electrica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T127888 NZ_CP041247:4018004-4018222 [Raoultella electrica]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACACTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGATCATCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT127888 WP_004858785.1 NZ_CP041247:4017603-4017977 [Raoultella electrica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT127888 NZ_CP041247:4017603-4017977 [Raoultella electrica]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGACCCGACGTCGGCTATCAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCACTTAATTATAAAATTAAGTACGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAACACGGCCGATTTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGCTTTGTCAACGCCAGTCGGGAAAATCCGGCAAGTCTTTCTTGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References