Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2624312..2625915 Replicon chromosome
Accession NZ_CP041247
Organism Raoultella electrica strain DSM 102253

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag Electrica_RS12565 Protein ID WP_141964605.1
Coordinates 2624312..2625643 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Electrica_RS12570 Protein ID WP_141964606.1
Coordinates 2625643..2625915 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Electrica_RS12550 2620205..2621119 - 915 WP_100684215.1 branched-chain amino acid ABC transporter permease LivH -
Electrica_RS12555 2621210..2622268 - 1059 WP_206057711.1 ABC transporter substrate-binding protein -
Electrica_RS12560 2622973..2624379 + 1407 WP_142255893.1 glycoside hydrolase family 10 protein -
Electrica_RS12565 2624312..2625643 - 1332 WP_141964605.1 type II toxin-antitoxin system HipA family toxin Toxin
Electrica_RS12570 2625643..2625915 - 273 WP_141964606.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
Electrica_RS12575 2626121..2626675 - 555 WP_141964607.1 sigma-70 family RNA polymerase sigma factor -
Electrica_RS12580 2626681..2627097 - 417 WP_141964608.1 hypothetical protein -
Electrica_RS12585 2627217..2628458 - 1242 WP_131049086.1 sensor domain-containing diguanylate cyclase -
Electrica_RS12590 2629010..2629702 + 693 WP_141964609.1 TenA family protein -
Electrica_RS12595 2629699..2630427 + 729 WP_160703375.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2497474..2654021 156547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49448.82 Da        Isoelectric Point: 7.4739

>T127887 WP_141964605.1 NZ_CP041247:c2625643-2624312 [Raoultella electrica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYR
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYRSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPQASIIQTASTRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSVKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIYLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFARQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPMYEAITDRLLWVHSRLQNAMAASPAG

Download         Length: 1332 bp

>T127887 NZ_CP041247:c2625643-2624312 [Raoultella electrica]
ATGGCCACTCTCGTGACATGGATGAACAATGAGCGGGTCGGCGAGCTTATCAAGCAGGCCAACGGCGCGCATCTTTTCCG
CTATGAAGAGGCGTGGATGCGCAATCCTCGCGCCAGGCCGCTCTCACTGTCGCTCCCGCTGCAGTACGGTAACATTACCG
ATGAGGCGGTGTTTAATTACTTTGACAATCTGCTGCCAGACAGTCCGCGGGTACGGGACCGCATTGTTAAGCGCTATCGG
GCGCGTTCAAAGCAGCCGTTTGATCTGCTGGCCGAGATCGGCCGGGACAGCGTCGGCGCGGTGACATTACTCCCGCCAGG
AGAAAATGCGCCCCGGGGAGCGCTAAGCTGGGAGCCGCTGGATAACCACGCCCTGGACGCGCTGCTGACGGCCTACCGGT
CGGATATACCGCTCGGGATGGTCAACGAACATGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGCGAGCAGTGGTGTATCCCGACGGGTACCACGCCGACCACCCACATCATTAAGCTGCCCATTGGCGAAAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATTTGTGTTTAGCTCTGGCTCGCGCGCTGG
GTTTTGCCGTTCCGCAGGCCAGTATTATTCAGACCGCCAGCACCAGGGCGCTGGCGGTTGAACGTTTCGATCGCCGCTGG
GCGCAGGAGAAGACGGTGCTGCTGCGTTTGCCGCAGGAAGACCTGTGTCAGGCCTTCGGCATTCCGTCATCGGTTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCAATTATGGCTTTTCTGGTTGGCTCCAGCGAGGCACTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTTCAGTGGCTGATTGGCGCAACCGATGGCCACGCGAAAAACTTCTCGATTTACCTCCAG
CCGGGCGGCAGCTACCGCTTAACCCCGTTCTACGACATTATCTCCGCGTTTCCGCTGCTTGGCGGGAAGGGGCTGCACCT
GAGCGATCTCAAGCTGTCAATGAGTCTGAAGGCCAGTAAAGGACGTAAAACGGAGATCCAGACGCTCTATCCGCGTCACT
TTCTCGCCACGGCTAAAGAGGTCGGGTTTGCCCGGCAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CGCGCGGTTGAGGCGGTAAAGGGGACTTTACCGCCTGACTTTTCACAACCGATGTATGAGGCGATCACCGATCGCTTACT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTCGCCGGCGGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10236.55 Da        Isoelectric Point: 6.9745

>AT127887 WP_141964606.1 NZ_CP041247:c2625915-2625643 [Raoultella electrica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDSGN
NRDNPQDLDW

Download         Length: 273 bp

>AT127887 NZ_CP041247:c2625915-2625643 [Raoultella electrica]
ATGAGCCCTTCACCAACGATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTACGCCAGAAAAACCAGTGGAC
GCAGAGCGACCTCGCGCAGCGAATGGGGATTAAACAGGCCACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCGCTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATAGCGGCAAT
AACCGTGATAACCCACAGGATCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References