Detailed information of TA system TA127870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 1728294..1729229
• Replicon: plasmid pEmeITTGR7c
• Accession: NZ_CP041241
• Organism: Ensifer mexicanus strain ITTG R7

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FKV68_RS31985
• Protein ID: WP_180942905.1
• Coordinates: 1728294..1728851 (-)
• Length: 186 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FKV68_RS31990
• Protein ID: WP_180942906.1
• Coordinates: 1728858..1729229 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKV68_RS31960	1723446..1724303	+	858	WP_180942900.1	sulfate ABC transporter permease subunit CysT	-
FKV68_RS31965	1724293..1725180	+	888	WP_180942901.1	sulfate ABC transporter permease subunit CysW	-
FKV68_RS31970	1725196..1726305	+	1110	WP_180942902.1	sulfate/molybdate ABC transporter ATP-binding protein	-
FKV68_RS31975	1726305..1727675	+	1371	WP_180942903.1	FAD-binding oxidoreductase	-
FKV68_RS31980	1727716..1728237	+	522	WP_180942904.1	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-
FKV68_RS31985	1728294..1728851	-	558	WP_180942905.1	RES domain-containing protein	Toxin
FKV68_RS31990	1728858..1729229	-	372	WP_180942906.1	DUF2384 domain-containing protein	Antitoxin
FKV68_RS31995	1729311..1730093	-	783	WP_180942908.1	crotonase/enoyl-CoA hydratase family protein	-
FKV68_RS32000	1730090..1730959	-	870	WP_180942910.1	hydroxymethylglutaryl-CoA lyase	-
FKV68_RS32005	1730956..1732944	-	1989	WP_180942911.1	acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha	-
FKV68_RS32010	1732962..1733345	-	384	WP_180942912.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katA / katB	1..1933675	1933675

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (24-178)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 186 a.a.
• Molecular weight: 20398.17 Da
• Isoelectric Point: 6.3322

>T127870 WP_180942905.1 NZ_CP041241:c1728851-1728294 [Ensifer mexicanus]
MRKSVSGFPSASRSNLEPPAEPMPLWRAFVPRWAHVPLSGEGAARFGGRWNPVGMPTIYAARELSTAWAEYNQGFVQHPA
LIVRLELYDALLADLTDANVLAELGLTDAIHRCEWRDGLDRGVVPQTHEVQADLSAREFHGVIYPSYMSPGGTCVALWRW
NGAGGPRLEVIDPEGRLPKSPASWL

Nucleotide

• Length: 558 bp

>T127870 NZ_CP041241:c1728851-1728294 [Ensifer mexicanus]
ATGAGGAAAAGTGTGAGCGGTTTTCCGTCCGCATCCCGCTCCAACTTAGAGCCGCCTGCCGAGCCGATGCCGCTCTGGCG
CGCCTTCGTGCCGCGGTGGGCCCATGTCCCGCTTTCCGGCGAAGGCGCGGCGCGCTTCGGCGGCAGATGGAATCCGGTGG
GCATGCCGACGATCTATGCCGCGCGCGAACTTTCGACGGCCTGGGCGGAATACAATCAGGGTTTCGTGCAGCATCCGGCG
CTGATCGTGCGGCTCGAGCTTTACGATGCGCTGCTTGCCGATCTCACGGACGCCAATGTTCTTGCGGAGCTTGGCCTGAC
GGATGCCATCCATCGATGCGAATGGCGAGACGGCCTCGACAGGGGCGTGGTGCCGCAAACCCACGAGGTGCAGGCGGATC
TCTCGGCCCGGGAGTTTCATGGCGTGATCTACCCGTCTTACATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGG
AACGGCGCGGGTGGGCCACGCCTTGAGGTCATAGATCCGGAAGGCAGGCTGCCGAAATCGCCGGCCTCCTGGCTCTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13073.27 Da
• Isoelectric Point: 9.9996

>AT127870 WP_180942906.1 NZ_CP041241:c1729229-1728858 [Ensifer mexicanus]
MVALNLEIPAARFGEDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKTGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLEAVRAGVYA

Nucleotide

• Length: 372 bp

>AT127870 NZ_CP041241:c1729229-1728858 [Ensifer mexicanus]
ATGGTCGCCCTCAACCTGGAAATTCCCGCCGCCCGCTTCGGGGAGGATCACTCCCCGTTTCTGTCGGCGCGTCTCGTCGC
CGACCGTCTGGGCGTAACGCTTGCCGAACTCGCCAAGCTGATTGGCGTCGCGCGGAACACGCTGACGGCCAAGACGGGTG
CCCGCAAGGTCGATAGCGCATTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGTGACGAGGCCCGT
GCCGTCATCTGGTTCAAGCACCAGCCGATTCCCGGCTGGGCCGGAAAGACGGCGTTCGATCTCGTCGGCGAAGGCAAGGC
CGACAAGGTTCTCGCTTACCTGGAAGCTGTTCGCGCCGGCGTCTACGCCTAG