Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 342376..342911 Replicon plasmid pEmeITTGR7c
Accession NZ_CP041241
Organism Ensifer mexicanus strain ITTG R7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FKV68_RS25750 Protein ID WP_180943359.1
Coordinates 342376..342651 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FKV68_RS25755 Protein ID WP_180943360.1
Coordinates 342651..342911 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKV68_RS25740 338709..339113 - 405 WP_180943357.1 DoxX family protein -
FKV68_RS25745 339485..342307 + 2823 WP_180943358.1 DNA translocase FtsK -
FKV68_RS25750 342376..342651 - 276 WP_180943359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKV68_RS25755 342651..342911 - 261 WP_180943360.1 ribbon-helix-helix domain-containing protein Antitoxin
FKV68_RS25760 343070..343957 - 888 WP_180943361.1 SDR family NAD(P)-dependent oxidoreductase -
FKV68_RS25765 343954..344739 - 786 WP_180943903.1 hypothetical protein -
FKV68_RS25770 344750..345337 - 588 WP_180943904.1 isoprenylcysteine carboxylmethyltransferase family protein -
FKV68_RS25775 345484..346074 - 591 WP_180943362.1 hypothetical protein -
FKV68_RS25780 346553..347149 - 597 WP_180943363.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / katB 1..1933675 1933675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10785.46 Da        Isoelectric Point: 10.2941

>T127868 WP_180943359.1 NZ_CP041241:c342651-342376 [Ensifer mexicanus]
MKLEWTTKAVSDLGRLYDFLAPVNRQAAARTVQALVTAPTRLLGQPRMGERLEEFDPREVRRILVGHYEMRYEIAHSTIY
VLRLWRTREDR

Download         Length: 276 bp

>T127868 NZ_CP041241:c342651-342376 [Ensifer mexicanus]
ATGAAGCTCGAGTGGACGACCAAGGCGGTTTCTGATCTAGGGCGCCTCTATGATTTCCTTGCGCCGGTCAATCGGCAAGC
AGCTGCCCGCACAGTGCAAGCGCTGGTAACGGCCCCAACGCGTCTGCTCGGGCAGCCGCGTATGGGCGAAAGGTTGGAAG
AGTTCGATCCCCGTGAGGTTCGCCGTATTCTCGTTGGCCATTACGAAATGCGTTACGAGATCGCCCACTCGACGATCTAC
GTGCTGAGGCTTTGGCGTACACGTGAGGATCGCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9625.97 Da        Isoelectric Point: 4.7914

>AT127868 WP_180943360.1 NZ_CP041241:c342911-342651 [Ensifer mexicanus]
METKVFTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWIDQEEERRRLTLEALADVDGGQVIDHQSVQAWADSLGSDK
PLPLPL

Download         Length: 261 bp

>AT127868 NZ_CP041241:c342911-342651 [Ensifer mexicanus]
ATGGAAACGAAGGTGTTTACAGCCCATGTACCGCTGCCGCTCGCCGAAAAGGTCGATCAAATCGCGGCACGGCTTGAGCG
TTCGCGCGGTTGGATCGTCAAGCAAGCACTGACTGCTTGGATTGACCAGGAAGAGGAGCGCCGGCGCTTGACGCTGGAAG
CGCTCGCCGACGTCGACGGTGGGCAGGTCATCGACCACCAGTCTGTGCAGGCTTGGGCCGATAGCCTCGGTAGCGACAAG
CCGCTGCCGCTACCATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References