Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1237427..1239293 Replicon chromosome
Accession NZ_CP041237
Organism Pandoraea pnomenusa strain M202

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FKQ53_RS05555 Protein ID WP_141570996.1
Coordinates 1237427..1238353 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FKQ53_RS05560 Protein ID WP_181762441.1
Coordinates 1238355..1239293 (+) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKQ53_RS05530 1232759..1233835 + 1077 WP_181762480.1 porin -
FKQ53_RS05535 1234161..1235030 + 870 WP_023597215.1 ABC transporter ATP-binding protein -
FKQ53_RS05540 1235071..1235853 + 783 WP_023597214.1 ABC transporter permease -
FKQ53_RS05545 1235870..1236661 + 792 WP_023597213.1 SDR family oxidoreductase -
FKQ53_RS05550 1236720..1237277 + 558 WP_023597212.1 cupin domain-containing protein -
FKQ53_RS05555 1237427..1238353 + 927 WP_141570996.1 alpha/beta fold hydrolase Toxin
FKQ53_RS05560 1238355..1239293 + 939 WP_181762441.1 IclR family transcriptional regulator Antitoxin
FKQ53_RS05565 1239290..1240096 + 807 WP_023597209.1 SDR family oxidoreductase -
FKQ53_RS05570 1240089..1241741 + 1653 WP_023873356.1 thiamine pyrophosphate-binding protein -
FKQ53_RS05575 1241734..1242552 + 819 WP_038620230.1 aspartate dehydrogenase -
FKQ53_RS05580 1242566..1244062 + 1497 WP_023597206.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, N-terminal

(48-96)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31609.75 Da        Isoelectric Point: 6.6037

>T127865 WP_141570996.1 NZ_CP041237:1237427-1238353 [Pandoraea pnomenusa]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALRLARVAVAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYA
AAKAGPVAVAVGAHDGVTPPASCQAIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T127865 NZ_CP041237:1237427-1238353 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCCGTCTTGCGCGCGTGGCGGTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTACGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACGCG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCACGATGGCGTCACCCCTCCCGCGAGCTGCCAGGCGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTCGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33937.70 Da        Isoelectric Point: 6.0582

>AT127865 WP_181762441.1 NZ_CP041237:1238355-1239293 [Pandoraea pnomenusa]
MAPANPKRAVAAAAIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT127865 NZ_CP041237:1238355-1239293 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGGCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCGGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATAAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References