Detailed information of TA system TA127864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 6524265..6524781
• Replicon: chromosome
• Accession: NZ_CP041236
• Organism: Pseudomonas azotoformans strain P45A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FKZ69_RS30625
• Protein ID: WP_092489413.1
• Coordinates: 6524265..6524552 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FKZ69_RS30630
• Protein ID: WP_092489412.1
• Coordinates: 6524542..6524781 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKZ69_RS30605	6519850..6520806	-	957	WP_141607539.1	FecR family protein	-
FKZ69_RS30610	6520803..6521336	-	534	WP_092355721.1	RNA polymerase sigma factor	-
FKZ69_RS30615	6521541..6522599	-	1059	WP_092489415.1	phosphorylcholine phosphatase	-
FKZ69_RS30620	6522842..6524233	+	1392	WP_092489414.1	L-cystine transporter	-
FKZ69_RS30625	6524265..6524552	-	288	WP_092489413.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FKZ69_RS30630	6524542..6524781	-	240	WP_092489412.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FKZ69_RS30635	6524865..6525377	-	513	WP_065946531.1	dihydrofolate reductase	-
FKZ69_RS30640	6525447..6526826	+	1380	WP_092489411.1	DUF2868 domain-containing protein	-
FKZ69_RS30645	6526819..6528186	+	1368	WP_141607540.1	DUF3482 domain-containing protein	-
FKZ69_RS30650	6528183..6528737	-	555	WP_092489409.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11240.01 Da
• Isoelectric Point: 9.9155

>T127864 WP_092489413.1 NZ_CP041236:c6524552-6524265 [Pseudomonas azotoformans]
MTYELGFDARALKEWHKLGDTVRQQFKKKLVEILNNPRIEASRLHGLPDCYKIKLRSTGYRLVYQVIDQEITVFVVAVDK
RERDEVYRKAADRLS

Nucleotide

• Length: 288 bp

>T127864 NZ_CP041236:c6524552-6524265 [Pseudomonas azotoformans]
ATGACCTATGAACTGGGTTTCGATGCACGGGCTTTGAAGGAATGGCACAAACTGGGCGATACCGTTCGTCAACAGTTTAA
AAAGAAGCTGGTCGAGATCCTGAACAATCCACGTATTGAAGCCAGCCGTCTGCATGGCTTGCCCGATTGCTACAAAATCA
AGCTACGCAGCACCGGTTATCGGTTGGTGTATCAAGTCATTGATCAGGAGATCACGGTGTTTGTCGTGGCTGTCGATAAG
CGTGAGCGTGATGAGGTTTACCGAAAGGCTGCTGATCGTTTGAGCTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8949.32 Da
• Isoelectric Point: 4.7962

>AT127864 WP_092489412.1 NZ_CP041236:c6524781-6524542 [Pseudomonas azotoformans]
MASINVRIDDDLKARAYHELEKLGVTPSELMRQALQYVADRGQLPFKPVLMTEEDEALLATVRERLAAPQRVKVSLDDL

Nucleotide

• Length: 240 bp

>AT127864 NZ_CP041236:c6524781-6524542 [Pseudomonas azotoformans]
ATGGCCTCTATCAACGTACGTATCGACGACGACCTTAAGGCTCGTGCTTATCACGAGTTGGAAAAGCTCGGCGTCACCCC
ATCGGAATTAATGCGTCAAGCCTTGCAGTACGTGGCAGACCGCGGCCAGTTACCTTTCAAGCCTGTCCTCATGACTGAAG
AGGATGAGGCATTGTTGGCAACAGTTCGGGAACGGCTGGCTGCGCCCCAGCGGGTGAAGGTCTCACTGGATGACCTATGA