Detailed information of TA system TA127858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 229545..230070
• Replicon: chromosome
• Accession: NZ_CP041235
• Organism: Sulfurimonas sp. S2-6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FJR45_RS01290
• Protein ID: WP_193151012.1
• Coordinates: 229786..230070 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FJR45_RS01285
• Protein ID: WP_193151011.1
• Coordinates: 229545..229802 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJR45_RS01245	224880..225164	-	285	WP_193151003.1	nucleotidyltransferase domain-containing protein	-
FJR45_RS01250	225167..226078	-	912	WP_193151004.1	sulfate adenylyltransferase subunit CysD	-
FJR45_RS01255	226082..226519	-	438	WP_193151005.1	hypothetical protein	-
FJR45_RS01260	226516..226800	-	285	WP_193151006.1	nucleotidyltransferase domain-containing protein	-
FJR45_RS01265	227118..227672	-	555	WP_193151007.1	IS630 family transposase	-
FJR45_RS01270	227636..228037	-	402	WP_193151008.1	winged helix-turn-helix domain-containing protein	-
FJR45_RS01275	228068..228778	-	711	WP_193151009.1	IS630 family transposase	-
FJR45_RS01280	228807..229109	-	303	WP_193151010.1	helix-turn-helix domain-containing protein	-
FJR45_RS01285	229545..229802	+	258	WP_193151011.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FJR45_RS01290	229786..230070	+	285	WP_193151012.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJR45_RS01295	230533..231156	-	624	WP_193151013.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
FJR45_RS01300	231399..232595	+	1197	WP_193151014.1	IS110 family transposase	-
FJR45_RS01305	232616..233650	-	1035	WP_193151868.1	transposase	-
FJR45_RS01310	233879..234151	-	273	WP_193151956.1	hypothetical protein	-
FJR45_RS01315	234138..234422	-	285	WP_193151015.1	toxin	-
FJR45_RS01320	234511..234726	-	216	Protein_257	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11324.06 Da
• Isoelectric Point: 10.0971

>T127858 WP_193151012.1 NZ_CP041235:229786-230070 [Sulfurimonas sp. S2-6]
MIYYLDFHPKALKEWSRLDYATKQQFHKKLKNRLSNPRVPKDRLSGYADVYKIKLRNAGYRLAYEVKDDEIVVFVISIGK
RENNEIYDNLKDRI

Nucleotide

• Length: 285 bp

>T127858 NZ_CP041235:229786-230070 [Sulfurimonas sp. S2-6]
ATGATTTATTATCTTGATTTTCATCCAAAAGCTTTGAAGGAGTGGAGTAGGTTGGATTATGCCACAAAACAACAATTCCA
CAAAAAACTCAAAAATAGATTGTCCAATCCAAGAGTACCAAAAGACAGACTTAGCGGATATGCAGATGTATATAAAATAA
AACTTAGAAATGCTGGATATAGATTGGCTTATGAGGTTAAAGATGACGAGATTGTGGTGTTTGTGATTAGTATAGGGAAG
AGAGAAAACAATGAAATTTATGATAATTTAAAAGATAGAATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9578.86 Da
• Isoelectric Point: 4.1265

>AT127858 WP_193151011.1 NZ_CP041235:229545-229802 [Sulfurimonas sp. S2-6]
MQPMLANYTASITELKQSPTQLLKDAGNEAIAILNHNVASAYLVPSDLYAKMMDIIDDYYLTRAVEERYNDGEKPIRVDI
DDLLS

Nucleotide

• Length: 258 bp

>AT127858 NZ_CP041235:229545-229802 [Sulfurimonas sp. S2-6]
ATGCAGCCAATGTTAGCAAATTATACAGCAAGTATTACAGAACTGAAGCAATCACCAACTCAGTTGCTGAAGGATGCAGG
AAACGAGGCAATAGCGATACTCAATCACAATGTTGCCAGCGCCTATCTGGTACCCAGCGATCTCTATGCCAAAATGATGG
ATATTATCGATGATTATTATCTGACACGAGCGGTAGAAGAGAGATATAATGATGGAGAAAAACCGATCAGAGTAGATATT
GATGATTTATTATCTTGA