Detailed information of TA system TA127855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2389416..2389993
• Replicon: chromosome
• Accession: NZ_CP041224
• Organism: Acinetobacter haemolyticus strain AN54

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AhaeAN54_RS11650
• Protein ID: WP_118902633.1
• Coordinates: 2389805..2389993 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AhaeAN54_RS11645
• Protein ID: WP_118902630.1
• Coordinates: 2389416..2389802 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN54_RS11620	2385671..2386324	-	654	WP_118902616.1	tail assembly protein	-
AhaeAN54_RS18310	2386341..2386517	-	177	WP_171479077.1	hypothetical protein	-
AhaeAN54_RS11625	2386577..2387332	-	756	WP_118902618.1	C40 family peptidase	-
AhaeAN54_RS11630	2387341..2388060	-	720	WP_118902620.1	phage minor tail protein L	-
AhaeAN54_RS11635	2388114..2388458	-	345	WP_118902623.1	phage tail protein	-
AhaeAN54_RS11640	2388662..2389312	-	651	WP_118902627.1	DUF1353 domain-containing protein	-
AhaeAN54_RS11645	2389416..2389802	-	387	WP_118902630.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AhaeAN54_RS11650	2389805..2389993	-	189	WP_118902633.1	type II toxin-antitoxin system HicA family toxin	Toxin
AhaeAN54_RS11655	2390092..2390481	-	390	WP_118902636.1	hypothetical protein	-
AhaeAN54_RS11660	2390468..2391268	-	801	WP_118902639.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2365255..2428754	63499

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7233.35 Da
• Isoelectric Point: 10.5461

>T127855 WP_118902633.1 NZ_CP041224:c2389993-2389805 [Acinetobacter haemolyticus]
MNSKDIIKRLEQEGWVKVGGKGDHEKFKHPEKSGHVVVPHPRKDMPIGTLRSIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T127855 NZ_CP041224:c2389993-2389805 [Acinetobacter haemolyticus]
ATGAACAGTAAAGACATTATCAAACGCTTGGAACAGGAAGGTTGGGTCAAGGTTGGTGGTAAAGGCGATCATGAAAAATT
TAAACATCCTGAGAAATCAGGTCATGTTGTGGTGCCACATCCTCGTAAAGATATGCCTATTGGAACATTGCGTAGTATAT
ATAAACAAGCTGGTTGGGAATGGAGGTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14432.18 Da
• Isoelectric Point: 4.3443

>AT127855 WP_118902630.1 NZ_CP041224:c2389802-2389416 [Acinetobacter haemolyticus]
MLYPVYVHKDQDSAYGLTFPDFDGCFSAADDMQDITRMAQEAVEVYFDGEDLDLPEPSSPEQWVGDDRFEGGYWLLVDID
TSKINSKSVRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAERLLHG

Nucleotide

• Length: 387 bp

>AT127855 NZ_CP041224:c2389802-2389416 [Acinetobacter haemolyticus]
ATGTTGTATCCAGTATATGTTCATAAAGACCAAGATTCTGCTTATGGTTTAACCTTTCCTGATTTTGATGGATGCTTTAG
TGCTGCCGATGATATGCAGGATATTACCCGTATGGCTCAAGAAGCTGTAGAGGTATATTTTGATGGTGAGGACTTAGATT
TACCTGAACCATCAAGCCCTGAGCAGTGGGTTGGTGATGATCGTTTTGAAGGCGGGTATTGGTTATTGGTTGATATAGAT
ACTTCTAAAATCAATAGCAAGTCTGTGCGTATCAATATCAGCATGCCTGAAGCATTGGTTAAACGTATTGATGCGGTTGC
CAAAAAGCAGCATTTGAGTCGTTCTGCATTTTTAGCCAAGAGTGCGGAACGATTGCTTCATGGGTAA