Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 735124..735763 Replicon chromosome
Accession NZ_CP041224
Organism Acinetobacter haemolyticus strain AN54

Toxin (Protein)


Gene name cptA Uniprot ID C0VNL5
Locus tag AhaeAN54_RS03615 Protein ID WP_005088316.1
Coordinates 735368..735763 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C0VNL4
Locus tag AhaeAN54_RS03610 Protein ID WP_005088318.1
Coordinates 735124..735381 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN54_RS03585 730197..730562 + 366 WP_004641032.1 50S ribosomal protein L17 -
AhaeAN54_RS03590 730727..731224 + 498 WP_004641030.1 GNAT family N-acetyltransferase -
AhaeAN54_RS03595 731603..733093 + 1491 WP_005086827.1 NAD(P)/FAD-dependent oxidoreductase -
AhaeAN54_RS03600 733216..733713 + 498 WP_005088321.1 DUF2059 domain-containing protein -
AhaeAN54_RS03605 733765..734937 - 1173 WP_005086825.1 acyl-CoA dehydrogenase family protein -
AhaeAN54_RS03610 735124..735381 + 258 WP_005088318.1 succinate dehydrogenase assembly factor 2 Antitoxin
AhaeAN54_RS03615 735368..735763 + 396 WP_005088316.1 hypothetical protein Toxin
AhaeAN54_RS03620 735974..736180 + 207 WP_026056364.1 hypothetical protein -
AhaeAN54_RS03625 736540..737583 + 1044 WP_004641019.1 hypothetical protein -
AhaeAN54_RS03630 737711..738292 + 582 WP_004641018.1 rhombosortase -
AhaeAN54_RS03635 738375..739076 + 702 WP_004678526.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 738375..739076 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 16153.44 Da        Isoelectric Point: 9.1954

>T127851 WP_005088316.1 NZ_CP041224:735368-735763 [Acinetobacter haemolyticus]
MSTADRVFVLKRSRFAFAFQLFIFIVLISLLYYLLPWFLWLVSFPLMLIAWVLLLKQPQLKHFEYLDDQLCSLCFSDEMQ
RIEQRKIRKMIDHQCYIVIYFYDSQCRPCVIWWDQLSILQWKKLRTWVKLA

Download         Length: 396 bp

>T127851 NZ_CP041224:735368-735763 [Acinetobacter haemolyticus]
ATGTCCACGGCTGATCGTGTTTTTGTGTTGAAACGCAGTCGTTTTGCATTTGCGTTTCAACTTTTTATTTTTATCGTACT
GATCAGTTTATTGTATTACTTACTTCCTTGGTTTTTATGGCTTGTTAGCTTTCCTTTGATGCTAATTGCTTGGGTATTAT
TACTCAAACAACCTCAGCTTAAACACTTTGAATATTTAGATGATCAGCTTTGCTCCTTGTGTTTTAGTGATGAGATGCAG
AGGATCGAGCAAAGGAAAATTCGAAAAATGATCGATCATCAATGTTATATCGTCATCTATTTTTATGACTCTCAATGTCG
ACCTTGTGTGATTTGGTGGGATCAATTGTCGATTTTACAGTGGAAAAAGCTCAGAACATGGGTCAAACTTGCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10012.44 Da        Isoelectric Point: 4.4558

>AT127851 WP_005088318.1 NZ_CP041224:735124-735381 [Acinetobacter haemolyticus]
MSEELTLEERKVIYRARRGLKEIDVYFDPYVKNCYLTADATEKALFAELVDQEDPDLLDWFMEVGEPPRPELKAFISKLK
QYVHG

Download         Length: 258 bp

>AT127851 NZ_CP041224:735124-735381 [Acinetobacter haemolyticus]
ATGTCTGAAGAATTGACACTAGAAGAACGTAAAGTGATTTATCGTGCGCGTCGTGGTTTGAAAGAAATCGATGTGTATTT
TGATCCTTATGTCAAAAATTGTTATCTCACAGCAGATGCGACTGAGAAAGCATTGTTTGCAGAGTTGGTAGATCAAGAAG
ATCCTGATTTACTGGATTGGTTCATGGAGGTGGGTGAACCTCCTCGTCCAGAGTTAAAAGCGTTTATTTCAAAATTAAAA
CAGTATGTCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6KJV0

Antitoxin

Source ID Structure
AlphaFold DB A0A372MSY6

References