Detailed information of TA system TA127850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 596473..597093
• Replicon: chromosome
• Accession: NZ_CP041224
• Organism: Acinetobacter haemolyticus strain AN54

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AhaeAN54_RS02885
• Protein ID: WP_008941148.1
• Coordinates: 596683..597093 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: AhaeAN54_RS02880
• Protein ID: WP_008941147.1
• Coordinates: 596473..596682 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN54_RS02855	591518..592939	+	1422	WP_005087020.1	FAD-dependent oxidoreductase	-
AhaeAN54_RS02860	593110..594000	+	891	Protein_543	metal-dependent hydrolase	-
AhaeAN54_RS02865	594174..594764	+	591	WP_008941144.1	LemA family protein	-
AhaeAN54_RS02870	594788..595846	+	1059	WP_008941145.1	TPM domain-containing protein	-
AhaeAN54_RS02875	595840..596400	+	561	WP_008941146.1	TPM domain-containing protein	-
AhaeAN54_RS02880	596473..596682	+	210	WP_008941147.1	antitoxin	Antitoxin
AhaeAN54_RS02885	596683..597093	+	411	WP_008941148.1	tRNA(fMet)-specific endonuclease VapC	Toxin
AhaeAN54_RS02890	597243..597614	+	372	Protein_549	Fic family protein	-
AhaeAN54_RS02900	598792..599622	+	831	Protein_551	Fic family protein	-
AhaeAN54_RS02905	600014..601178	+	1165	Protein_552	IS3-like element ISAba22 family transposase	-
AhaeAN54_RS02910	601250..601471	+	222	WP_008941151.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	572984..700630	127646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15384.81 Da
• Isoelectric Point: 8.8849

>T127850 WP_008941148.1 NZ_CP041224:596683-597093 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTIKQRPLAVKERFNAVSTQLCISSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T127850 NZ_CP041224:596683-597093 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTTGATACCAATATTGTGATTTATACAATAAAACAAAGACCACTGGCGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTTTGTATCAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCACTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT127850 WP_008941147.1 NZ_CP041224:596473-596682 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT127850 NZ_CP041224:596473-596682 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8