Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 54645..55158 Replicon chromosome
Accession NZ_CP041224
Organism Acinetobacter haemolyticus strain AN54

Toxin (Protein)


Gene name yoeB Uniprot ID A0A558EQR2
Locus tag AhaeAN54_RS00255 Protein ID WP_043975117.1
Coordinates 54895..55158 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag AhaeAN54_RS00250 Protein ID WP_000557943.1
Coordinates 54645..54908 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AhaeAN54_RS00240 50172..50864 + 693 WP_198421056.1 HipA domain-containing protein -
AhaeAN54_RS00245 50882..54229 - 3348 WP_125316849.1 DEAD/DEAH box helicase -
AhaeAN54_RS00250 54645..54908 + 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AhaeAN54_RS00255 54895..55158 + 264 WP_043975117.1 Txe/YoeB family addiction module toxin Toxin
AhaeAN54_RS00260 55230..55385 - 156 Protein_51 IS5/IS1182 family transposase -
AhaeAN54_RS00265 55431..55763 - 333 Protein_52 transposase -
AhaeAN54_RS00270 56073..56537 - 465 WP_008942447.1 GNAT family N-acetyltransferase -
AhaeAN54_RS00275 56663..58015 - 1353 WP_118902195.1 MHS family MFS transporter -
AhaeAN54_RS00280 58134..59159 - 1026 WP_017395165.1 enoyl-CoA hydratase/isomerase family protein -
AhaeAN54_RS00285 59173..59946 - 774 WP_118902192.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10680.10 Da        Isoelectric Point: 7.8508

>T127849 WP_043975117.1 NZ_CP041224:54895-55158 [Acinetobacter haemolyticus]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
VQCWFHY

Download         Length: 264 bp

>T127849 NZ_CP041224:54895-55158 [Acinetobacter haemolyticus]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGAAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
GTTCAATGTTGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT127849 WP_000557943.1 NZ_CP041224:54645-54908 [Acinetobacter haemolyticus]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT127849 NZ_CP041224:54645-54908 [Acinetobacter haemolyticus]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGACAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A558EQR2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References