Detailed information of TA system TA127848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 1604577..1605559
• Replicon: chromosome
• Accession: NZ_CP041222
• Organism: Porphyrobacter sp. YT40

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: E2E27_RS07490
• Protein ID: WP_141458365.1
• Coordinates: 1605074..1605559 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: E2E27_RS07485
• Protein ID: WP_199799099.1
• Coordinates: 1604577..1605077 (+)
• Length: 167 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2E27_RS07465	1599734..1602751	-	3018	WP_141458361.1	conjugative relaxase	-
E2E27_RS07470	1602748..1603512	-	765	WP_141458362.1	hypothetical protein	-
E2E27_RS07475	1603868..1604134	-	267	WP_141458363.1	hypothetical protein	-
E2E27_RS07480	1604134..1604391	-	258	WP_199799098.1	helix-turn-helix domain-containing protein	-
E2E27_RS07485	1604577..1605077	+	501	WP_199799099.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
E2E27_RS07490	1605074..1605559	+	486	WP_141458365.1	RES family NAD+ phosphorylase	Toxin
E2E27_RS07495	1605561..1606553	-	993	WP_141458366.1	hypothetical protein	-
E2E27_RS07500	1606583..1607734	-	1152	WP_141458367.1	site-specific integrase	-
E2E27_RS07510	1608220..1609050	+	831	WP_141458368.1	DUF1134 domain-containing protein	-
E2E27_RS07515	1609111..1610289	+	1179	WP_141461680.1	aspartate/tyrosine/aromatic aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-153)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (39-100)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17669.00 Da
• Isoelectric Point: 6.7215

>T127848 WP_141458365.1 NZ_CP041222:1605074-1605559 [Porphyrobacter sp. YT40]
VSVSVWRIATDTKNYEADDLSGKGAEITGGRWNDKGTPLVYTSTNRSLAALETIVHLNSGGLPLNRYLVEIVILDDVWNA
AEGIDHTTAPVGWDAEPASRTSSDYGTRWARAATSLLLRVPSVIVPEESNVLINPCHPDIAAIKARKVRKWIYDARIVRS
M

Nucleotide

• Length: 486 bp

>T127848 NZ_CP041222:1605074-1605559 [Porphyrobacter sp. YT40]
GTGAGTGTATCGGTCTGGCGCATTGCGACCGATACGAAGAACTATGAAGCGGACGATCTCAGCGGCAAGGGGGCGGAAAT
CACCGGCGGTCGCTGGAACGACAAGGGGACGCCGCTGGTCTACACCTCGACGAACCGGTCGCTCGCCGCGCTTGAGACCA
TCGTGCACCTCAACTCGGGCGGCCTGCCGCTCAACCGCTATCTCGTCGAGATCGTCATCCTGGATGATGTCTGGAACGCG
GCGGAAGGGATCGATCACACTACCGCGCCGGTGGGGTGGGACGCCGAACCGGCGAGCCGCACATCATCGGATTATGGCAC
CCGCTGGGCCAGAGCAGCGACCAGCCTGCTGCTGCGCGTCCCCTCGGTGATCGTGCCGGAGGAAAGCAATGTGCTGATCA
ACCCGTGCCATCCCGACATCGCGGCGATCAAGGCCCGCAAGGTGCGCAAGTGGATCTATGATGCAAGGATCGTGCGGAGC
ATGTGA

Antitoxin

Protein

• Length: 167 a.a.
• Molecular weight: 17683.33 Da
• Isoelectric Point: 9.8026

>AT127848 WP_199799099.1 NZ_CP041222:1604577-1605077 [Porphyrobacter sp. YT40]
MATSAIYSGNVRTARGSKLATPKTGGGYRELFAASPQARIAMIRQGVPAIEAKRLVQALGVEQKVFYQALGLKTATVNRK
ITQSEQLASDESERLLGVARLIGQVEAIVAESGDPKGFDAPEWLSRWLREPLPALGGTPPMALLDTMEGQAMVAEALSRI
QSGAYA

Nucleotide

• Length: 501 bp

>AT127848 NZ_CP041222:1604577-1605077 [Porphyrobacter sp. YT40]
ATGGCTACATCTGCGATCTACAGCGGCAACGTCAGAACAGCGCGCGGCAGCAAGCTTGCAACGCCCAAGACAGGCGGCGG
GTATCGCGAGCTCTTCGCCGCCTCACCCCAAGCGCGGATTGCAATGATCCGGCAGGGCGTCCCCGCCATCGAGGCCAAGC
GGCTGGTGCAGGCGCTCGGGGTCGAGCAGAAGGTGTTCTATCAGGCACTCGGGCTGAAGACCGCCACCGTGAACCGCAAG
ATCACCCAGAGCGAGCAGCTCGCCAGTGATGAAAGCGAGCGCCTGCTTGGCGTGGCGCGGTTGATTGGGCAGGTCGAGGC
GATCGTCGCCGAGTCTGGCGATCCCAAGGGCTTCGATGCACCCGAATGGCTGTCGCGCTGGCTGCGTGAGCCGTTGCCCG
CGCTTGGCGGCACCCCGCCGATGGCTCTGCTTGATACAATGGAAGGTCAGGCCATGGTCGCCGAGGCGCTATCCCGCATC
CAGAGCGGAGCCTATGCGTGA