Detailed information of TA system TA127846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3700433..3700949
• Replicon: chromosome
• Accession: NZ_CP041216
• Organism: Shewanella glacialimarina strain TZS-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FJ709_RS16165
• Protein ID: WP_226411085.1
• Coordinates: 3700665..3700949 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FJ709_RS16160
• Protein ID: WP_226411083.1
• Coordinates: 3700433..3700675 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ709_RS16150 (FJ709_16115)	3695788..3697944	+	2157	WP_226411079.1	M3 family metallopeptidase	-
FJ709_RS16155 (FJ709_16120)	3698152..3699870	-	1719	WP_226411081.1	hypothetical protein	-
FJ709_RS16160 (FJ709_16125)	3700433..3700675	+	243	WP_226411083.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FJ709_RS16165 (FJ709_16130)	3700665..3700949	+	285	WP_226411085.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJ709_RS16170 (FJ709_16135)	3701715..3702641	+	927	WP_226411087.1	restriction endonuclease	-
FJ709_RS16175 (FJ709_16140)	3703543..3704295	-	753	WP_226411089.1	phosphoadenylyl-sulfate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11112.82 Da
• Isoelectric Point: 9.6732

>T127846 WP_226411085.1 NZ_CP041216:3700665-3700949 [Shewanella glacialimarina]
MTYELEFDPRALKEWHKLGDTIRQQFKKKLAEVQVNPRVEANQLRELPDCYKIKLRSAGYRLIYQVQDERITVFVVAVGK
REGAEAYKDADKRL

Nucleotide

• Length: 285 bp

>T127846 NZ_CP041216:3700665-3700949 [Shewanella glacialimarina]
ATGACCTATGAATTGGAGTTTGATCCCCGTGCTTTGAAGGAATGGCACAAGTTGGGTGATACCATTCGCCAGCAGTTTAA
GAAGAAGTTGGCTGAGGTGCAGGTTAACCCTCGTGTCGAAGCCAATCAGTTACGAGAATTACCAGATTGTTACAAAATCA
AGTTGCGTAGCGCGGGTTATCGATTGATATACCAAGTGCAAGATGAGCGGATCACTGTTTTTGTCGTAGCAGTTGGAAAA
AGAGAAGGCGCTGAAGCTTACAAAGATGCTGATAAACGTTTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8861.25 Da
• Isoelectric Point: 4.5408

>AT127846 WP_226411083.1 NZ_CP041216:3700433-3700675 [Shewanella glacialimarina]
MGTINIRVDDELKTRSYAALEKLGVTPSELLRQTLEYVAQRGVLPFKPVLLTDEDQALLELAKARLADPQPGVKVTLDDL

Nucleotide

• Length: 243 bp

>AT127846 NZ_CP041216:3700433-3700675 [Shewanella glacialimarina]
ATGGGAACCATTAATATTCGTGTCGATGATGAGCTAAAAACACGCTCTTATGCGGCTTTGGAAAAACTCGGTGTGACGCC
ATCAGAGTTGCTACGCCAAACATTGGAATATGTAGCGCAAAGAGGGGTGCTGCCATTTAAGCCGGTACTGTTAACCGATG
AGGACCAAGCCCTTTTAGAATTAGCAAAGGCTCGCTTGGCCGATCCACAACCTGGCGTGAAGGTTACTTTGGATGACCTA
TGA