Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2212776..2213320 Replicon chromosome
Accession NZ_CP041207
Organism Mycobacterium tuberculosis strain MT-0080

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FKO20_RS10655 Protein ID WP_003409896.1
Coordinates 2212776..2213072 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FKO20_RS10660 Protein ID WP_003409899.1
Coordinates 2213069..2213320 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKO20_RS10600 2207809..2208159 - 351 WP_003899096.1 hypothetical protein -
FKO20_RS10605 2208170..2209072 - 903 WP_003899097.1 hypothetical protein -
FKO20_RS10610 2209093..2209284 - 192 WP_003409876.1 hypothetical protein -
FKO20_RS10615 2209285..2209581 - 297 WP_003409877.1 hypothetical protein -
FKO20_RS10620 2209821..2210036 + 216 WP_003409878.1 antitoxin -
FKO20_RS10625 2210033..2210344 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FKO20_RS21735 2210318..2210839 - 522 WP_003904745.1 hypothetical protein -
FKO20_RS10635 2210814..2211191 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FKO20_RS10640 2211233..2211682 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FKO20_RS10645 2211679..2212224 + 546 WP_003899098.1 SecB-like chaperone -
FKO20_RS10650 2212113..2212727 - 615 WP_003901296.1 hypothetical protein -
FKO20_RS10655 2212776..2213072 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKO20_RS10660 2213069..2213320 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FKO20_RS10665 2213307..2213801 + 495 WP_003899099.1 hypothetical protein -
FKO20_RS10670 2213961..2214368 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FKO20_RS10675 2214372..2214644 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FKO20_RS10680 2214677..2215897 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FKO20_RS10695 2216796..2217593 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T127816 WP_003409896.1 NZ_CP041207:c2213072-2212776 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T127816 NZ_CP041207:c2213072-2212776 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT127816 WP_003409899.1 NZ_CP041207:c2213320-2213069 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT127816 NZ_CP041207:c2213320-2213069 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References