Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3202759..3203408 Replicon chromosome
Accession NZ_CP041203
Organism Cellulomonas sp. Y8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FKM96_RS14475 Protein ID WP_147795832.1
Coordinates 3202989..3203408 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FKM96_RS14470 Protein ID WP_147795831.1
Coordinates 3202759..3202992 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKM96_RS14450 3197811..3199196 - 1386 WP_147795827.1 DNA recombination protein RmuC -
FKM96_RS14455 3199248..3200015 + 768 WP_147795828.1 ABC transporter ATP-binding protein -
FKM96_RS14460 3199991..3201556 + 1566 WP_147795829.1 hypothetical protein -
FKM96_RS14465 3201596..3202681 + 1086 WP_147795830.1 redox-regulated ATPase YchF -
FKM96_RS14470 3202759..3202992 + 234 WP_147795831.1 Arc family DNA-binding protein Antitoxin
FKM96_RS14475 3202989..3203408 + 420 WP_147795832.1 type II toxin-antitoxin system VapC family toxin Toxin
FKM96_RS14480 3203405..3204538 + 1134 WP_210417456.1 methyltransferase -
FKM96_RS14485 3204548..3205339 - 792 WP_147795834.1 SDR family oxidoreductase -
FKM96_RS14490 3205448..3205951 + 504 WP_147795835.1 MarR family transcriptional regulator -
FKM96_RS14495 3206167..3206610 - 444 WP_147795836.1 DUF1801 domain-containing protein -
FKM96_RS14500 3206712..3207155 - 444 WP_147795837.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(11-42)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15020.13 Da        Isoelectric Point: 5.2141

>T127781 WP_147795832.1 NZ_CP041203:3202989-3203408 [Cellulomonas sp. Y8]
VIVLDTNVISEVFRPEPEPRVVTWLEALTGEVAITAVTLAELLAGVRRLPDGQRRSALTERIHLAVEPYRATRAILPFDV
AAAEQYADVLAARERAGRPIHSADAQIAAICRVHGATCATRNVKDFDGTGVDVVDPWAA

Download         Length: 420 bp

>T127781 NZ_CP041203:3202989-3203408 [Cellulomonas sp. Y8]
GTGATCGTGCTCGACACCAACGTCATCTCGGAGGTCTTCCGGCCGGAGCCCGAGCCGCGCGTGGTGACGTGGCTCGAGGC
CCTGACCGGTGAGGTCGCGATCACGGCCGTGACGCTCGCGGAGCTCCTGGCGGGAGTGCGGCGGCTGCCCGACGGGCAGC
GCCGGTCCGCGCTCACCGAGCGGATCCACCTGGCCGTCGAGCCCTACCGCGCGACCCGGGCCATCCTCCCGTTCGACGTC
GCGGCGGCCGAGCAGTACGCGGACGTGCTCGCCGCGCGGGAGCGGGCGGGGCGACCGATCCACTCGGCGGATGCGCAGAT
CGCGGCGATCTGCCGCGTGCACGGGGCGACGTGCGCGACGCGGAACGTCAAGGACTTCGACGGGACCGGGGTCGACGTCG
TCGACCCGTGGGCCGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8292.36 Da        Isoelectric Point: 6.4632

>AT127781 WP_147795831.1 NZ_CP041203:3202759-3202992 [Cellulomonas sp. Y8]
MSTIVVRGLDESVKQQLAAQAKEHGRSMEAEARDILTQAARRPHIGVALLRAARQAGGVDDLVVPERTDDARAVDFG

Download         Length: 234 bp

>AT127781 NZ_CP041203:3202759-3202992 [Cellulomonas sp. Y8]
ATGTCCACCATCGTCGTCCGCGGGCTCGACGAGTCCGTCAAGCAGCAGCTCGCCGCCCAGGCGAAGGAGCACGGCCGCTC
CATGGAGGCCGAGGCGCGGGACATCCTCACGCAGGCCGCCCGCCGGCCCCACATCGGCGTCGCCCTGCTCCGTGCGGCGC
GTCAGGCCGGCGGTGTCGACGACCTCGTGGTGCCGGAGCGCACCGACGACGCGCGGGCGGTGGACTTCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References