Detailed information of TA system TA127780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES(toxin)
• Location: 1687200..1688070
• Replicon: chromosome
• Accession: NZ_CP041203
• Organism: Cellulomonas sp. Y8

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: FKM96_RS07590
• Protein ID: WP_147794729.1
• Coordinates: 1687200..1687760 (-)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: FKM96_RS07595
• Protein ID: WP_210417388.1
• Coordinates: 1687765..1688070 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKM96_RS07565	1682327..1682926	+	600	WP_013115601.1	cadmium resistance transporter	-
FKM96_RS07570	1683239..1684612	-	1374	WP_174773798.1	mercury(II) reductase	-
FKM96_RS07575	1684674..1685072	+	399	WP_166771975.1	heavy metal-responsive transcriptional regulator	-
FKM96_RS07580	1685571..1686254	+	684	WP_168216913.1	ankyrin repeat domain-containing protein	-
FKM96_RS07585	1686427..1687022	+	596	Protein_1501	recombinase family protein	-
FKM96_RS07590	1687200..1687760	-	561	WP_147794729.1	RES domain-containing protein	Toxin
FKM96_RS07595	1687765..1688070	-	306	WP_210417388.1	hypothetical protein	Antitoxin
FKM96_RS07600	1688195..1689358	+	1164	WP_147794731.1	hypothetical protein	-
FKM96_RS07605	1689986..1691098	+	1113	WP_147794732.1	hypothetical protein	-
FKM96_RS07610	1691230..1691970	-	741	WP_147794733.1	hypothetical protein	-
FKM96_RS07615	1692251..1692631	-	381	WP_147794734.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1618927..1708648	89721

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (27-162)

Antitoxin

• Cro/C1-type helix-turn-helix domain (5-55)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 19840.20 Da
• Isoelectric Point: 4.3688

>T127780 WP_147794729.1 NZ_CP041203:c1687760-1687200 [Cellulomonas sp. Y8]
VLDEAVVERVNDLGTVIWSGTTYRHASAAFDGLSGRGAVVHGGRWNPPDSFETLYLATPVVTCMAELERLAAAQSLDPVD
LLNARRPRMLHTITVHEAAVLDLRSDAALASVGLERADITDDDWSGCQAIGHAAHFLGHGGVLAPSATGDGLVLAAFESR
LDPDQLSLTESVQLTEDLYRELISPT

Nucleotide

• Length: 561 bp

>T127780 NZ_CP041203:c1687760-1687200 [Cellulomonas sp. Y8]
GTGCTGGACGAAGCAGTCGTCGAGAGAGTCAACGACCTCGGCACGGTCATCTGGAGCGGCACCACCTACAGGCATGCCAG
TGCCGCATTCGACGGCCTCTCGGGCCGCGGCGCTGTGGTGCACGGTGGACGCTGGAACCCTCCGGACAGTTTCGAGACCC
TCTACCTCGCCACTCCCGTGGTGACGTGCATGGCTGAACTCGAGCGCCTTGCCGCGGCTCAGTCTCTCGACCCGGTCGAC
CTGCTCAACGCCCGTCGCCCGCGGATGCTGCACACAATCACTGTGCACGAGGCCGCCGTCCTGGACCTGCGCAGCGATGC
CGCGCTCGCCAGCGTCGGACTGGAGCGCGCAGACATCACCGACGACGACTGGTCCGGCTGTCAGGCCATCGGTCATGCCG
CGCATTTCCTCGGCCACGGCGGGGTGCTCGCTCCCTCGGCGACCGGAGATGGCCTTGTACTCGCCGCGTTCGAATCCCGC
CTTGATCCCGATCAGCTCAGCCTCACCGAGTCGGTCCAGCTCACCGAGGACCTGTATCGCGAGCTCATCTCCCCAACCTG
A

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11013.61 Da
• Isoelectric Point: 5.0481

>AT127780 WP_210417388.1 NZ_CP041203:c1688070-1687765 [Cellulomonas sp. Y8]
VIATLGLTQEEVGSIVDASPRTVARWSSGQVTPQKLNKQRLLELAYVADVAADVFPPDKVNLWLLSPNRQLDHDTPAERI
RAGHFKDVLGLMEAIADGVVI

Nucleotide

• Length: 306 bp

>AT127780 NZ_CP041203:c1688070-1687765 [Cellulomonas sp. Y8]
GTGATCGCCACCCTCGGGCTCACGCAGGAAGAGGTCGGCTCGATCGTTGACGCATCGCCGCGCACGGTCGCCCGGTGGTC
CAGTGGTCAGGTCACGCCACAGAAGCTGAACAAGCAGCGGCTTCTCGAACTTGCCTACGTCGCTGACGTGGCGGCGGACG
TGTTCCCACCGGACAAGGTGAACCTATGGCTTCTGTCTCCGAACAGGCAGCTCGACCACGACACCCCTGCGGAGCGCATC
AGAGCAGGCCACTTCAAGGATGTCCTCGGCCTCATGGAGGCGATCGCTGACGGCGTGGTGATCTGA