127779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1501091..1501607 Replicon chromosome
Accession NZ_CP041202
Organism Vibrio parahaemolyticus strain Vb0624

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag FKM99_RS16650 Protein ID WP_005464459.1
Coordinates 1501338..1501607 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag FKM99_RS16645 Protein ID WP_005483180.1
Coordinates 1501091..1501345 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKM99_RS16585 1496527..1496817 + 291 WP_141180089.1 hypothetical protein -
FKM99_RS16590 1496835..1496924 + 90 Protein_1414 DUF3265 domain-containing protein -
FKM99_RS16595 1497440..1497853 + 414 WP_141180090.1 hypothetical protein -
FKM99_RS16600 1497989..1498456 + 468 WP_141180091.1 NUDIX domain-containing protein -
FKM99_RS16605 1498431..1498571 + 141 WP_153645912.1 DUF3265 domain-containing protein -
FKM99_RS16610 1498604..1499098 + 495 WP_140283229.1 GNAT family N-acetyltransferase -
FKM99_RS16620 1499553..1499663 + 111 WP_169567097.1 DUF3265 domain-containing protein -
FKM99_RS16625 1499736..1500254 + 519 WP_033907392.1 hypothetical protein -
FKM99_RS16640 1500857..1500988 + 132 WP_141180092.1 DUF3265 domain-containing protein -
FKM99_RS16645 1501091..1501345 + 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FKM99_RS16650 1501338..1501607 + 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
FKM99_RS16655 1501786..1502268 + 483 WP_141180093.1 DUF2007 domain-containing protein -
FKM99_RS16660 1502904..1503368 + 465 WP_021485101.1 DUF2846 domain-containing protein -
FKM99_RS16670 1504513..1505625 + 1113 WP_141180094.1 DUF4236 domain-containing protein -
FKM99_RS16675 1505628..1505732 + 105 WP_095760931.1 DUF3265 domain-containing protein -
FKM99_RS16680 1505766..1506305 + 540 WP_141180095.1 hypothetical protein -
FKM99_RS16685 1506299..1506412 + 114 WP_153646152.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1402117..1529274 127157
- inside Integron - - 1402641..1521793 119152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T127779 WP_005464459.1 NZ_CP041202:1501338-1501607 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T127779 NZ_CP041202:1501338-1501607 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT127779 WP_005483180.1 NZ_CP041202:1501091-1501345 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT127779 NZ_CP041202:1501091-1501345 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References