Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1463560..1464088 Replicon chromosome
Accession NZ_CP041202
Organism Vibrio parahaemolyticus strain Vb0624

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag FKM99_RS16245 Protein ID WP_005377002.1
Coordinates 1463560..1463850 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FKM99_RS16250 Protein ID WP_005377003.1
Coordinates 1463840..1464088 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKM99_RS26835 1460030..1460173 + 144 WP_169567107.1 DUF3265 domain-containing protein -
FKM99_RS16195 1460201..1460677 + 477 WP_065090387.1 hypothetical protein -
FKM99_RS16200 1460692..1460784 + 93 WP_141180065.1 DUF3265 domain-containing protein -
FKM99_RS16205 1460812..1461288 + 477 WP_141180066.1 GNAT family N-acetyltransferase -
FKM99_RS16210 1461285..1461407 + 123 WP_012841700.1 DUF3265 domain-containing protein -
FKM99_RS16215 1461545..1461784 + 240 WP_141180042.1 hypothetical protein -
FKM99_RS16225 1462416..1462805 + 390 WP_021453025.1 hypothetical protein -
FKM99_RS16235 1462962..1463426 + 465 WP_141180068.1 ASCH domain-containing protein -
FKM99_RS16240 1463419..1463541 + 123 WP_169567093.1 DUF3265 domain-containing protein -
FKM99_RS16245 1463560..1463850 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKM99_RS16250 1463840..1464088 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FKM99_RS16260 1464324..1465118 - 795 WP_141180069.1 NYN domain-containing protein -
FKM99_RS16265 1465815..1465907 + 93 WP_141180070.1 DUF3265 domain-containing protein -
FKM99_RS16270 1466006..1466710 + 705 WP_141180071.1 hypothetical protein -
FKM99_RS16275 1466882..1467337 + 456 WP_171971538.1 GNAT family N-acetyltransferase -
FKM99_RS16280 1467334..1467462 + 129 WP_141180550.1 DUF3265 domain-containing protein -
FKM99_RS16285 1467805..1467915 + 111 WP_169567091.1 DUF3265 domain-containing protein -
FKM99_RS16295 1468509..1469036 + 528 WP_010644336.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1402117..1529274 127157
- inside Integron - - 1402641..1521793 119152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T127777 WP_005377002.1 NZ_CP041202:c1463850-1463560 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T127777 NZ_CP041202:c1463850-1463560 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTACGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT127777 WP_005377003.1 NZ_CP041202:c1464088-1463840 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT127777 NZ_CP041202:c1464088-1463840 [Vibrio parahaemolyticus]
ATGACCACCAGAATCCTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAAAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References