Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 683782..685610 Replicon chromosome
Accession NZ_CP041202
Organism Vibrio parahaemolyticus strain Vb0624

Toxin (Protein)


Gene name hipA Uniprot ID A0A7Y0XBH1
Locus tag FKM99_RS11985 Protein ID WP_031858072.1
Coordinates 684249..685610 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FKM99_RS11980 Protein ID WP_031858073.1
Coordinates 683782..684264 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKM99_RS11960 679461..680993 - 1533 WP_141179865.1 bifunctional GNAT family N-acetyltransferase/carbon-nitrogen hydrolase family protein -
FKM99_RS11965 681129..682019 - 891 WP_141179866.1 LysR family transcriptional regulator -
FKM99_RS11970 682419..682982 + 564 WP_005455971.1 porin family protein -
FKM99_RS11975 683113..683295 - 183 Protein_598 lipase family protein -
FKM99_RS11980 683782..684264 - 483 WP_031858073.1 helix-turn-helix domain-containing protein Antitoxin
FKM99_RS11985 684249..685610 - 1362 WP_031858072.1 type II toxin-antitoxin system HipA family toxin Toxin
FKM99_RS11990 686107..686898 - 792 WP_031858071.1 metallophosphoesterase -
FKM99_RS11995 687145..687435 + 291 Protein_602 hypothetical protein -
FKM99_RS12000 687518..687904 - 387 WP_025501826.1 transcriptional regulator -
FKM99_RS12005 689161..689883 + 723 WP_025559098.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 670079..704850 34771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51397.16 Da        Isoelectric Point: 4.8126

>T127775 WP_031858072.1 NZ_CP041202:c685610-684249 [Vibrio parahaemolyticus]
MEELTVQAFLRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLTFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRVKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWMKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCLNLKQRLALRGVPEQILEMPAVGLNHIPEKLTKWGLL

Download         Length: 1362 bp

>T127775 NZ_CP041202:c685610-684249 [Vibrio parahaemolyticus]
ATGGAAGAACTAACCGTACAAGCTTTTCTCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAATCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAACGTTTCTAGACGATATTATG
CCTAGTGGTGCTAGTAGACGATACTGGGTCAAACACCTGGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAGTAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAACAAAGAGGGGCAGCCGCA
GGTGGTGCAACTGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGCGGTTTCGATCATGGATCTGGTAGCGAAAA
AATATGGATTGACCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGATGTTCAAATTATTGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACATCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGATGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCGTAGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAACTAGAGGTTACTGCAAGTAAATGCCTTAATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATACCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17549.08 Da        Isoelectric Point: 10.8446

>AT127775 WP_031858073.1 NZ_CP041202:c684264-683782 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLA
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT127775 NZ_CP041202:c684264-683782 [Vibrio parahaemolyticus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAACCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGCG
GAGCTAACACAAGGGCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0XBH1

Antitoxin

Source ID Structure

References