Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5494021..5494659 Replicon chromosome
Accession NZ_CP041189
Organism Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NIBR502773_RS25530 Protein ID WP_115487910.1
Coordinates 5494021..5494203 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z6MU10
Locus tag NIBR502773_RS25535 Protein ID WP_065947540.1
Coordinates 5494258..5494659 (+) Length 134 a.a.

Genomic Context

NIBR502773_RS25510NIBR502773_RS25515NIBR502773_RS25530NIBR502773_RS25535NIBR502773_RS25540NIBR502773_RS25545NIBR502773_RS25550NIBR502773_RS25505NIBR502773_RS25520NIBR502773_RS25525
Location: 5489967..5490275 (309 bp)
Type: Others
Protein ID: WP_027603185.1
Location: 5490352..5491545 (1194 bp)
Type: Others
Protein ID: WP_141157248.1
Location: 5494021..5494203 (183 bp)
Type: Toxin
Protein ID: WP_115487910.1
Location: 5494258..5494659 (402 bp)
Type: Antitoxin
Protein ID: WP_065947540.1
Location: 5494940..5495284 (345 bp)
Type: Others
Protein ID: WP_065926228.1
Location: 5495790..5498495 (2706 bp)
Type: Others
Protein ID: WP_141157249.1
Location: 5498512..5499228 (717 bp)
Type: Others
Protein ID: WP_141157250.1
Location: 5489054..5489611 (558 bp)
Type: Others
Protein ID: WP_027603184.1
Location: 5491508..5491780 (273 bp)
Type: Others
Protein ID: WP_027603187.1
Location: 5491912..5493408 (1497 bp)
Type: Others
Protein ID: WP_065942144.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NIBR502773_RS255055489054..5489611-558WP_027603184.1XRE family transcriptional regulator-
NIBR502773_RS255105489967..5490275+309WP_027603185.1RcnB family protein-
NIBR502773_RS255155490352..5491545+1194WP_141157248.1MFS transporter-
NIBR502773_RS255205491508..5491780-273WP_027603187.1DUF1652 domain-containing protein-
NIBR502773_RS255255491912..5493408-1497WP_065942144.1helix-turn-helix transcriptional regulator-
NIBR502773_RS255305494021..5494203+183WP_115487910.1type II toxin-antitoxin system HicA family toxinToxin
NIBR502773_RS255355494258..5494659+402WP_065947540.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NIBR502773_RS255405494940..5495284+345WP_065926228.1FKBP-type peptidyl-prolyl cis-trans isomerase-
NIBR502773_RS255455495790..5498495+2706WP_141157249.1magnesium-translocating P-type ATPase-
NIBR502773_RS255505498512..5499228+717WP_141157250.1MgtC/SapB family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6680.83 Da        Isoelectric Point: 11.1475

>T127770 WP_115487910.1 NZ_CP041189:5494021-5494203 [Pseudomonas sp. NIBRBAC000502773]
MRSREVIDLLVADGWFEVAVKGSHHQFKHPVKRGRVTVPHPKSEIAKGTLHSILKSAGLK

Download         Length: 183 bp

>T127770 NZ_CP041189:5494021-5494203 [Pseudomonas sp. NIBRBAC000502773]
ATGAGAAGTCGAGAGGTGATTGACCTGCTGGTTGCGGATGGTTGGTTTGAGGTGGCGGTGAAGGGCAGTCATCATCAGTT
CAAGCACCCCGTGAAGCGGGGAAGAGTCACCGTCCCTCATCCCAAGTCAGAGATTGCCAAGGGCACTCTGCACAGTATTC
TCAAATCAGCCGGTCTCAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14477.23 Da        Isoelectric Point: 4.5928

>AT127770 WP_065947540.1 NZ_CP041189:5494258-5494659 [Pseudomonas sp. NIBRBAC000502773]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGGSFSEALDNVREALALHLEGLVADQEQLPQALEVDAHLGNPDFAGGVWAIV
DFDLTPYLGKSVRFNASLPEHLLQRIDERVQKDHRYASRSGFLATAALRELSA

Download         Length: 402 bp

>AT127770 NZ_CP041189:5494258-5494659 [Pseudomonas sp. NIBRBAC000502773]
ATGAAATTCCCAGTGGTAGTACACAAAGATGCTGATTCGGATTACAGCGTGACCGTCCCTGATGTGCCGGGGTGTTTCTC
GGCGGGCGGGTCTTTTTCCGAAGCGCTGGACAATGTACGTGAGGCATTGGCTCTCCACCTCGAAGGCCTGGTTGCCGATC
AGGAACAGCTTCCTCAGGCGCTGGAGGTTGATGCCCATTTGGGTAATCCGGATTTTGCCGGTGGTGTCTGGGCGATAGTC
GACTTTGACCTCACGCCTTATCTGGGGAAATCAGTGCGGTTCAATGCCTCTCTGCCGGAACACCTCTTGCAGCGGATTGA
CGAGCGTGTGCAAAAGGATCATCGCTATGCATCGCGGTCAGGTTTTTTGGCGACGGCAGCGCTGCGTGAGCTCTCTGCGT
AA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7Z6MU10

References