Detailed information of TA system TA127770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5494021..5494659
• Replicon: chromosome
• Accession: NZ_CP041189
• Organism: Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NIBR502773_RS25530
• Protein ID: WP_115487910.1
• Coordinates: 5494021..5494203 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A7Z6MU10
• Locus tag: NIBR502773_RS25535
• Protein ID: WP_065947540.1
• Coordinates: 5494258..5494659 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIBR502773_RS25505	5489054..5489611	-	558	WP_027603184.1	XRE family transcriptional regulator	-
NIBR502773_RS25510	5489967..5490275	+	309	WP_027603185.1	RcnB family protein	-
NIBR502773_RS25515	5490352..5491545	+	1194	WP_141157248.1	MFS transporter	-
NIBR502773_RS25520	5491508..5491780	-	273	WP_027603187.1	DUF1652 domain-containing protein	-
NIBR502773_RS25525	5491912..5493408	-	1497	WP_065942144.1	helix-turn-helix transcriptional regulator	-
NIBR502773_RS25530	5494021..5494203	+	183	WP_115487910.1	type II toxin-antitoxin system HicA family toxin	Toxin
NIBR502773_RS25535	5494258..5494659	+	402	WP_065947540.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NIBR502773_RS25540	5494940..5495284	+	345	WP_065926228.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
NIBR502773_RS25545	5495790..5498495	+	2706	WP_141157249.1	magnesium-translocating P-type ATPase	-
NIBR502773_RS25550	5498512..5499228	+	717	WP_141157250.1	MgtC/SapB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6680.83 Da
• Isoelectric Point: 11.1475

>T127770 WP_115487910.1 NZ_CP041189:5494021-5494203 [Pseudomonas sp. NIBRBAC000502773]
MRSREVIDLLVADGWFEVAVKGSHHQFKHPVKRGRVTVPHPKSEIAKGTLHSILKSAGLK

Nucleotide

• Length: 183 bp

>T127770 NZ_CP041189:5494021-5494203 [Pseudomonas sp. NIBRBAC000502773]
ATGAGAAGTCGAGAGGTGATTGACCTGCTGGTTGCGGATGGTTGGTTTGAGGTGGCGGTGAAGGGCAGTCATCATCAGTT
CAAGCACCCCGTGAAGCGGGGAAGAGTCACCGTCCCTCATCCCAAGTCAGAGATTGCCAAGGGCACTCTGCACAGTATTC
TCAAATCAGCCGGTCTCAAATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14477.23 Da
• Isoelectric Point: 4.5928

>AT127770 WP_065947540.1 NZ_CP041189:5494258-5494659 [Pseudomonas sp. NIBRBAC000502773]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGGSFSEALDNVREALALHLEGLVADQEQLPQALEVDAHLGNPDFAGGVWAIV
DFDLTPYLGKSVRFNASLPEHLLQRIDERVQKDHRYASRSGFLATAALRELSA

Nucleotide

• Length: 402 bp

>AT127770 NZ_CP041189:5494258-5494659 [Pseudomonas sp. NIBRBAC000502773]
ATGAAATTCCCAGTGGTAGTACACAAAGATGCTGATTCGGATTACAGCGTGACCGTCCCTGATGTGCCGGGGTGTTTCTC
GGCGGGCGGGTCTTTTTCCGAAGCGCTGGACAATGTACGTGAGGCATTGGCTCTCCACCTCGAAGGCCTGGTTGCCGATC
AGGAACAGCTTCCTCAGGCGCTGGAGGTTGATGCCCATTTGGGTAATCCGGATTTTGCCGGTGGTGTCTGGGCGATAGTC
GACTTTGACCTCACGCCTTATCTGGGGAAATCAGTGCGGTTCAATGCCTCTCTGCCGGAACACCTCTTGCAGCGGATTGA
CGAGCGTGTGCAAAAGGATCATCGCTATGCATCGCGGTCAGGTTTTTTGGCGACGGCAGCGCTGCGTGAGCTCTCTGCGT
AA

Structures

Antitoxin

• AlphaFold DB: A0A7Z6MU10