Detailed information of TA system TA127769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5232319..5232923
• Replicon: chromosome
• Accession: NZ_CP041189
• Organism: Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NIBR502773_RS24290
• Protein ID: WP_141157143.1
• Coordinates: 5232319..5232507 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: NIBR502773_RS24295
• Protein ID: WP_141157144.1
• Coordinates: 5232519..5232923 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIBR502773_RS24265	5227928..5228518	+	591	WP_141157139.1	histidine phosphatase family protein	-
NIBR502773_RS24270	5228618..5228764	+	147	WP_141157140.1	PhnM protein	-
NIBR502773_RS24275	5228764..5229336	+	573	WP_065939949.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
NIBR502773_RS24280	5229732..5231213	+	1482	WP_141157141.1	M10 family metallopeptidase C-terminal domain-containing protein	-
NIBR502773_RS24285	5231243..5232124	-	882	WP_141157142.1	LysR family transcriptional regulator	-
NIBR502773_RS24290	5232319..5232507	+	189	WP_141157143.1	type II toxin-antitoxin system HicA family toxin	Toxin
NIBR502773_RS24295	5232519..5232923	+	405	WP_141157144.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NIBR502773_RS24300	5232920..5234116	-	1197	WP_141157145.1	MFS transporter	-
NIBR502773_RS24305	5234258..5234881	+	624	WP_141157146.1	hypothetical protein	-
NIBR502773_RS24310	5234937..5235941	-	1005	WP_027607038.1	sulfate ABC transporter substrate-binding protein	-
NIBR502773_RS24315	5236038..5236862	-	825	WP_115488098.1	ion transporter	-
NIBR502773_RS24320	5236894..5237769	-	876	WP_141157147.1	urea transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.46 Da
• Isoelectric Point: 11.2249

>T127769 WP_141157143.1 NZ_CP041189:5232319-5232507 [Pseudomonas sp. NIBRBAC000502773]
VQSRLLIKELQEAGWVLDRVTGSHPTFTHRYNPYTIPVPHPKKYLPLGTIRSIRKRAGLFQF

Nucleotide

• Length: 189 bp

>T127769 NZ_CP041189:5232319-5232507 [Pseudomonas sp. NIBRBAC000502773]
GTGCAAAGCAGGCTATTGATCAAGGAGCTGCAAGAGGCGGGTTGGGTGCTGGATCGGGTCACGGGCAGTCATCCTACTTT
TACCCACCGCTATAACCCGTACACGATCCCGGTGCCGCATCCGAAGAAGTATCTGCCGCTGGGCACCATCAGAAGCATCA
GGAAACGTGCCGGGCTGTTTCAGTTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14700.61 Da
• Isoelectric Point: 4.5000

>AT127769 WP_141157144.1 NZ_CP041189:5232519-5232923 [Pseudomonas sp. NIBRBAC000502773]
MQYPISIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQEIAAEGGVIPMPTSVADHHTHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT127769 NZ_CP041189:5232519-5232923 [Pseudomonas sp. NIBRBAC000502773]
ATGCAATACCCAATCTCTATCGAATGGGGCGATGACTTCACCGCCACCGGTATCCAGATCCCCGATATTCCAGGTGCAGT
CACCGCCGGGGACAGTTTCGAAGAGGCCTACAACGCCGCGGTGGAAGTCGCGCACATCCTGCTGCAGGAGATCGCCGCAG
AAGGCGGGGTGATTCCGATGCCAACGTCGGTGGCCGATCATCACACCCACGAAGATTACGCCGGGATGGGCTGGGGTATG
CTCGAACTGGACATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGCTATGTCATCCAGCGAAT
CGACCGCTATGTGCGCGAGCACAAGGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCTTTGGAGAAGTTGGTGCGTT
CTTAG