Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4904003..4904618 Replicon chromosome
Accession NZ_CP041189
Organism Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)


Gene name hicA Uniprot ID I4KFU3
Locus tag NIBR502773_RS22645 Protein ID WP_003189411.1
Coordinates 4904436..4904618 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1X7DFW9
Locus tag NIBR502773_RS22640 Protein ID WP_027604351.1
Coordinates 4904003..4904413 (-) Length 137 a.a.

Genomic Context

NIBR502773_RS22605NIBR502773_RS22610NIBR502773_RS22615NIBR502773_RS22625NIBR502773_RS22655NIBR502773_RS22660NIBR502773_RS22670NIBR502773_RS22595NIBR502773_RS22600NIBR502773_RS22620NIBR502773_RS22630NIBR502773_RS22635NIBR502773_RS22640NIBR502773_RS22645NIBR502773_RS22650NIBR502773_RS30715NIBR502773_RS22675
Location: 4899785..4900195 (411 bp)
Type: Others
Protein ID: WP_141156985.1
Location: 4900250..4900891 (642 bp)
Type: Others
Protein ID: WP_141156986.1
Location: 4901010..4901537 (528 bp)
Type: Others
Protein ID: WP_027604356.1
Location: 4902196..4902978 (783 bp)
Type: Others
Protein ID: WP_141156987.1
Location: 4905775..4906938 (1164 bp)
Type: Others
Protein ID: WP_141156991.1
Location: 4906935..4908125 (1191 bp)
Type: Others
Protein ID: WP_141156992.1
Location: 4908777..4909016 (240 bp)
Type: Others
Protein ID: WP_027604347.1
Location: 4899172..4899456 (285 bp)
Type: Others
Protein ID: WP_141156984.1
Location: 4899446..4899685 (240 bp)
Type: Others
Protein ID: WP_065928241.1
Location: 4901592..4902017 (426 bp)
Type: Others
Protein ID: WP_027604355.1
Location: 4902979..4903479 (501 bp)
Type: Others
Protein ID: WP_141156988.1
Location: 4903573..4903914 (342 bp)
Type: Others
Protein ID: WP_141156989.1
Location: 4904003..4904413 (411 bp)
Type: Antitoxin
Protein ID: WP_027604351.1
Location: 4904436..4904618 (183 bp)
Type: Toxin
Protein ID: WP_003189411.1
Location: 4904783..4905679 (897 bp)
Type: Others
Protein ID: WP_141156990.1
Location: 4908131..4908373 (243 bp)
Type: Others
Protein ID: WP_177414150.1
Location: 4909085..4909390 (306 bp)
Type: Others
Protein ID: WP_141156993.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NIBR502773_RS225954899172..4899456-285WP_141156984.1type II toxin-antitoxin system RelE/ParE family toxin-
NIBR502773_RS226004899446..4899685-240WP_065928241.1ribbon-helix-helix protein, CopG family-
NIBR502773_RS226054899785..4900195+411WP_141156985.1fosfomycin resistance glutathione transferase-
NIBR502773_RS226104900250..4900891+642WP_141156986.1LysE family translocator-
NIBR502773_RS226154901010..4901537+528WP_027604356.1DUF4142 domain-containing protein-
NIBR502773_RS226204901592..4902017-426WP_027604355.1low affinity iron permease family protein-
NIBR502773_RS226254902196..4902978+783WP_141156987.1GNAT family N-acetyltransferase-
NIBR502773_RS226304902979..4903479-501WP_141156988.1methylated-DNA--[protein]-cysteine S-methyltransferase-
NIBR502773_RS226354903573..4903914-342WP_141156989.1hypothetical protein-
NIBR502773_RS226404904003..4904413-411WP_027604351.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
NIBR502773_RS226454904436..4904618-183WP_003189411.1type II toxin-antitoxin system HicA family toxinToxin
NIBR502773_RS226504904783..4905679-897WP_141156990.1LysR family transcriptional regulator-
NIBR502773_RS226554905775..4906938+1164WP_141156991.1MFS transporter-
NIBR502773_RS226604906935..4908125+1191WP_141156992.1MFS transporter-
NIBR502773_RS307154908131..4908373-243WP_177414150.1hypothetical protein-
NIBR502773_RS226704908777..4909016+240WP_027604347.1hypothetical protein-
NIBR502773_RS226754909085..4909390-306WP_141156993.1metal ABC transporter ATPase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6804.01 Da        Isoelectric Point: 10.7532

>T127768 WP_003189411.1 NZ_CP041189:c4904618-4904436 [Pseudomonas sp. NIBRBAC000502773]
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T127768 NZ_CP041189:c4904618-4904436 [Pseudomonas sp. NIBRBAC000502773]
GTGGATAGCCGATACTTGATAGGTCACATCGTCGCAGACGGCTGGTACCTGGTTCGCATCAGAGGCAGTCATCACCACTT
CAAGCACCCGACGAAGCCTGGCCTGGTGACGATCCCCCACCCAAAGAAAGACCTGTTGGACAAAACCGCCAAGAGCATTT
TGAAACAAGCTCTGTTGAGTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14800.71 Da        Isoelectric Point: 4.5911

>AT127768 WP_027604351.1 NZ_CP041189:c4904413-4904003 [Pseudomonas sp. NIBRBAC000502773]
MLYPIAISTGDHDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQDR

Download         Length: 411 bp

>AT127768 NZ_CP041189:c4904413-4904003 [Pseudomonas sp. NIBRBAC000502773]
ATGCTGTACCCCATCGCAATTTCAACCGGTGACCACGATCACGCCTGGGGCGTGGAAGTCCCGGATATTCCCGGTTGCTA
CTCTGCCGGTGACGACCTGGACGACGCCATGGCCATGGCGCGCGAAGCCATCGAAGGGCACTTCGAAATCCTCGCGGAAG
ACGGCGCGCCGATCCCGAGCGCCCAGAAGGTCACCGTGCATGCCGCCAACCCTCAGTACGCCGGCTGCACTTGGGCGGTT
GTAGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACGTTGCCGGGCTACCTGCTCAACCGCAT
CGATGAATACGTACTGCACCACCCGGAGGAAAAAAGCCGCTCCGGCTTCCTCGCGTCGGCGGCGCTCAAGGTGCTGCAAC
AGGATCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1X7DFI9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1X7DFW9

References