Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4904003..4904618 Replicon chromosome
Accession NZ_CP041189
Organism Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)


Gene name hicA Uniprot ID I4KFU3
Locus tag NIBR502773_RS22645 Protein ID WP_003189411.1
Coordinates 4904436..4904618 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1X7DFW9
Locus tag NIBR502773_RS22640 Protein ID WP_027604351.1
Coordinates 4904003..4904413 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIBR502773_RS22595 4899172..4899456 - 285 WP_141156984.1 type II toxin-antitoxin system RelE/ParE family toxin -
NIBR502773_RS22600 4899446..4899685 - 240 WP_065928241.1 ribbon-helix-helix protein, CopG family -
NIBR502773_RS22605 4899785..4900195 + 411 WP_141156985.1 fosfomycin resistance glutathione transferase -
NIBR502773_RS22610 4900250..4900891 + 642 WP_141156986.1 LysE family translocator -
NIBR502773_RS22615 4901010..4901537 + 528 WP_027604356.1 DUF4142 domain-containing protein -
NIBR502773_RS22620 4901592..4902017 - 426 WP_027604355.1 low affinity iron permease family protein -
NIBR502773_RS22625 4902196..4902978 + 783 WP_141156987.1 GNAT family N-acetyltransferase -
NIBR502773_RS22630 4902979..4903479 - 501 WP_141156988.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
NIBR502773_RS22635 4903573..4903914 - 342 WP_141156989.1 hypothetical protein -
NIBR502773_RS22640 4904003..4904413 - 411 WP_027604351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIBR502773_RS22645 4904436..4904618 - 183 WP_003189411.1 type II toxin-antitoxin system HicA family toxin Toxin
NIBR502773_RS22650 4904783..4905679 - 897 WP_141156990.1 LysR family transcriptional regulator -
NIBR502773_RS22655 4905775..4906938 + 1164 WP_141156991.1 MFS transporter -
NIBR502773_RS22660 4906935..4908125 + 1191 WP_141156992.1 MFS transporter -
NIBR502773_RS30715 4908131..4908373 - 243 WP_177414150.1 hypothetical protein -
NIBR502773_RS22670 4908777..4909016 + 240 WP_027604347.1 hypothetical protein -
NIBR502773_RS22675 4909085..4909390 - 306 WP_141156993.1 metal ABC transporter ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6804.01 Da        Isoelectric Point: 10.7532

>T127768 WP_003189411.1 NZ_CP041189:c4904618-4904436 [Pseudomonas sp. NIBRBAC000502773]
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T127768 NZ_CP041189:c4904618-4904436 [Pseudomonas sp. NIBRBAC000502773]
GTGGATAGCCGATACTTGATAGGTCACATCGTCGCAGACGGCTGGTACCTGGTTCGCATCAGAGGCAGTCATCACCACTT
CAAGCACCCGACGAAGCCTGGCCTGGTGACGATCCCCCACCCAAAGAAAGACCTGTTGGACAAAACCGCCAAGAGCATTT
TGAAACAAGCTCTGTTGAGTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14800.71 Da        Isoelectric Point: 4.5911

>AT127768 WP_027604351.1 NZ_CP041189:c4904413-4904003 [Pseudomonas sp. NIBRBAC000502773]
MLYPIAISTGDHDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQDR

Download         Length: 411 bp

>AT127768 NZ_CP041189:c4904413-4904003 [Pseudomonas sp. NIBRBAC000502773]
ATGCTGTACCCCATCGCAATTTCAACCGGTGACCACGATCACGCCTGGGGCGTGGAAGTCCCGGATATTCCCGGTTGCTA
CTCTGCCGGTGACGACCTGGACGACGCCATGGCCATGGCGCGCGAAGCCATCGAAGGGCACTTCGAAATCCTCGCGGAAG
ACGGCGCGCCGATCCCGAGCGCCCAGAAGGTCACCGTGCATGCCGCCAACCCTCAGTACGCCGGCTGCACTTGGGCGGTT
GTAGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACGTTGCCGGGCTACCTGCTCAACCGCAT
CGATGAATACGTACTGCACCACCCGGAGGAAAAAAGCCGCTCCGGCTTCCTCGCGTCGGCGGCGCTCAAGGTGCTGCAAC
AGGATCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7DFI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7DFW9

References