Detailed information of TA system TA127767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 4899172..4899685
• Replicon: chromosome
• Accession: NZ_CP041189
• Organism: Pseudomonas sp. NIBRBAC000502773

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NIBR502773_RS22595
• Protein ID: WP_141156984.1
• Coordinates: 4899172..4899456 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1WCL4
• Locus tag: NIBR502773_RS22600
• Protein ID: WP_065928241.1
• Coordinates: 4899446..4899685 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIBR502773_RS22575	4895357..4896298	+	942	WP_141156980.1	hydroxymethylglutaryl-CoA lyase	-
NIBR502773_RS22580	4896358..4897689	+	1332	WP_141156981.1	MFS transporter	-
NIBR502773_RS22585	4897690..4898178	-	489	WP_141156982.1	DMT family transporter	-
NIBR502773_RS22590	4898247..4899164	+	918	WP_141156983.1	LysR family transcriptional regulator	-
NIBR502773_RS22595	4899172..4899456	-	285	WP_141156984.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NIBR502773_RS22600	4899446..4899685	-	240	WP_065928241.1	ribbon-helix-helix protein, CopG family	Antitoxin
NIBR502773_RS22605	4899785..4900195	+	411	WP_141156985.1	fosfomycin resistance glutathione transferase	-
NIBR502773_RS22610	4900250..4900891	+	642	WP_141156986.1	LysE family translocator	-
NIBR502773_RS22615	4901010..4901537	+	528	WP_027604356.1	DUF4142 domain-containing protein	-
NIBR502773_RS22620	4901592..4902017	-	426	WP_027604355.1	low affinity iron permease family protein	-
NIBR502773_RS22625	4902196..4902978	+	783	WP_141156987.1	GNAT family N-acetyltransferase	-
NIBR502773_RS22630	4902979..4903479	-	501	WP_141156988.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
NIBR502773_RS22635	4903573..4903914	-	342	WP_141156989.1	hypothetical protein	-
NIBR502773_RS22640	4904003..4904413	-	411	WP_027604351.1	type II toxin-antitoxin system HicB family antitoxin	-
NIBR502773_RS22645	4904436..4904618	-	183	WP_003189411.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-82)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10970.65 Da
• Isoelectric Point: 10.0872

>T127767 WP_141156984.1 NZ_CP041189:c4899456-4899172 [Pseudomonas sp. NIBRBAC000502773]
MQVEWLRTALKNLDDEAAYIAQENPKAAHEFVQAIMVGLGHVAEFPAVGKEGRVPGTREWVVPRWPYIVPYRIRDGRLQV
MRFFHTRRQPPTSW

Nucleotide

• Length: 285 bp

>T127767 NZ_CP041189:c4899456-4899172 [Pseudomonas sp. NIBRBAC000502773]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAAGAACCTTGATGATGAAGCCGCGTACATTGCGCAGGAAAATCCCAAAGC
CGCCCATGAGTTCGTCCAGGCCATCATGGTTGGGCTAGGACATGTCGCTGAATTTCCTGCTGTGGGAAAGGAAGGTCGAG
TGCCAGGAACGCGGGAGTGGGTAGTGCCTCGATGGCCTTACATCGTTCCCTACCGGATTCGAGATGGACGATTACAAGTG
ATGCGATTTTTTCATACACGTCGCCAGCCACCGACATCCTGGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8582.79 Da
• Isoelectric Point: 5.0958

>AT127767 WP_065928241.1 NZ_CP041189:c4899685-4899446 [Pseudomonas sp. NIBRBAC000502773]
MSVMSLRIPEDIAATLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGEFATAAEVKAVADKWRTNAG

Nucleotide

• Length: 240 bp

>AT127767 NZ_CP041189:c4899685-4899446 [Pseudomonas sp. NIBRBAC000502773]
ATGTCTGTTATGTCCCTACGCATACCCGAAGACATCGCCGCCACGCTTGCCAGTCTCGCCAAGGCGACCGGGCGCAGCAA
ATCCTTTCTCGCAGTCGATGCATTACGCGAATACTTGACGCGCGAAGCGTGGCAAATCGAAGAAATTCAAAAAGCATTGA
AAGAAGCAGACGCAGGCGAGTTCGCAACGGCTGCGGAGGTAAAAGCCGTCGCCGATAAATGGCGCACCAATGCAGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1WCL4