Detailed information of TA system TA127766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4142919..4143473
• Replicon: chromosome
• Accession: NZ_CP041188
• Organism: Pseudarthrobacter sp. NIBRBAC000502772

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NIBR502772_RS19220
• Protein ID: WP_141141368.1
• Coordinates: 4142919..4143185 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: NIBR502772_RS19225
• Protein ID: WP_141141369.1
• Coordinates: 4143192..4143473 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIBR502772_RS19185	4138028..4138534	-	507	WP_141141363.1	hypothetical protein	-
NIBR502772_RS19190	4138531..4139154	-	624	WP_141142167.1	signal peptidase I	-
NIBR502772_RS19195	4139159..4139770	-	612	WP_141141364.1	hypothetical protein	-
NIBR502772_RS19200	4139842..4140384	-	543	WP_141141365.1	alternate-type signal peptide domain-containing protein	-
NIBR502772_RS19205	4140619..4141836	-	1218	WP_141141366.1	MFS transporter	-
NIBR502772_RS19210	4141957..4142298	+	342	WP_141141367.1	hypothetical protein	-
NIBR502772_RS19215	4142426..4142755	-	330	WP_141142168.1	hypothetical protein	-
NIBR502772_RS19220	4142919..4143185	-	267	WP_141141368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NIBR502772_RS19225	4143192..4143473	-	282	WP_141141369.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NIBR502772_RS19230	4143602..4144099	+	498	WP_141141370.1	SRPBCC domain-containing protein	-
NIBR502772_RS19235	4144109..4144861	+	753	WP_141141371.1	NAD(P)H-binding protein	-
NIBR502772_RS19240	4145085..4146374	-	1290	WP_141141372.1	MinD/ParA family protein	-
NIBR502772_RS22495	4146715..4146852	-	138	WP_168223575.1	hypothetical protein	-
NIBR502772_RS22500	4146960..4147103	-	144	WP_168223576.1	hypothetical protein	-
NIBR502772_RS19245	4147199..4147714	+	516	WP_141141373.1	GNAT family N-acetyltransferase	-
NIBR502772_RS19250	4147729..4148031	-	303	WP_141141374.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10120.61 Da
• Isoelectric Point: 9.8755

>T127766 WP_141141368.1 NZ_CP041188:c4143185-4142919 [Pseudarthrobacter sp. NIBRBAC000502772]
VAYEVIFSPTARRDLLSVPPRILPAIIEFVYGDLSRNPQRVGKALERDLAGFLSARRGPYRVLYSIDEEHNSISILRVDH
RADVYRPR

Nucleotide

• Length: 267 bp

>T127766 NZ_CP041188:c4143185-4142919 [Pseudarthrobacter sp. NIBRBAC000502772]
GTGGCATATGAGGTCATTTTCTCGCCCACCGCACGCCGGGACCTGCTGTCCGTGCCTCCCCGGATACTGCCGGCCATCAT
CGAATTCGTCTACGGCGACCTCTCCAGAAACCCTCAGCGGGTAGGCAAGGCCTTGGAGCGGGACCTGGCCGGCTTCCTCT
CGGCCAGGCGTGGCCCCTACCGCGTCCTGTACTCCATTGATGAGGAACACAACAGCATCAGTATCCTGCGGGTCGACCAC
CGAGCCGACGTGTACCGGCCCAGGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10164.43 Da
• Isoelectric Point: 4.3210

>AT127766 WP_141141369.1 NZ_CP041188:c4143473-4143192 [Pseudarthrobacter sp. NIBRBAC000502772]
MQTLPISAVKARLSELVDAASVTHDQVVITKNGVPAAVIIGTEEWEALQESLFWLSQPNIREDLAQAQQDIAEGKGLSEE
QIRAEFGVPKHQS

Nucleotide

• Length: 282 bp

>AT127766 NZ_CP041188:c4143473-4143192 [Pseudarthrobacter sp. NIBRBAC000502772]
ATGCAAACGTTACCGATTTCTGCCGTAAAGGCCAGGCTTTCCGAGCTCGTGGACGCCGCGTCTGTGACCCATGATCAGGT
GGTTATCACCAAGAACGGCGTACCCGCGGCCGTGATCATCGGAACCGAAGAATGGGAGGCGCTGCAGGAATCTCTGTTCT
GGCTTTCCCAGCCGAACATCCGGGAAGACCTTGCCCAGGCCCAACAGGACATAGCCGAGGGTAAGGGCCTGTCCGAGGAG
CAGATCCGGGCAGAGTTCGGCGTCCCCAAGCACCAGAGCTGA