Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 5881..6403 Replicon plasmid p12367A
Accession NZ_CP041177
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF12367v2

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag FKO11_RS22970 Protein ID WP_000220561.1
Coordinates 6122..6403 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FKO11_RS22965 Protein ID WP_000121743.1
Coordinates 5881..6132 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKO11_RS22940 2004..2426 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
FKO11_RS22945 2494..2940 - 447 WP_001074384.1 hypothetical protein -
FKO11_RS22950 2944..3786 - 843 WP_000435064.1 replication initiation protein -
FKO11_RS22955 3807..4646 - 840 WP_024129959.1 replication initiation protein -
FKO11_RS22965 5881..6132 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FKO11_RS22970 6122..6403 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKO11_RS22975 6642..6734 - 93 Protein_9 IS6 family transposase -
FKO11_RS22980 6900..8099 - 1200 WP_072648941.1 IS91 family transposase -
FKO11_RS22985 8109..8297 - 189 WP_000957857.1 hypothetical protein -
FKO11_RS24195 8527..8631 + 105 WP_032409716.1 hypothetical protein -
FKO11_RS22990 8760..9017 + 258 WP_000764642.1 hypothetical protein -
FKO11_RS22995 9075..9851 - 777 WP_000015958.1 site-specific integrase -
FKO11_RS23000 9848..10591 - 744 WP_000129823.1 hypothetical protein -
FKO11_RS23005 10642..10992 - 351 WP_000493378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111764 111764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T127759 WP_000220561.1 NZ_CP041177:6122-6403 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T127759 NZ_CP041177:6122-6403 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT127759 WP_000121743.1 NZ_CP041177:5881-6132 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT127759 NZ_CP041177:5881-6132 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References