Detailed information of TA system TA127758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 9596..10118
• Replicon: plasmid p12519B
• Accession: NZ_CP041175
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF12519v2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: FKO10_RS24385
• Protein ID: WP_000220561.1
• Coordinates: 9596..9877 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: FKO10_RS24390
• Protein ID: WP_000121743.1
• Coordinates: 9867..10118 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKO10_RS24345	5577..6122	-	546	WP_000757692.1	hypothetical protein	-
FKO10_RS24720	6117..6191	-	75	Protein_8	DNA distortion polypeptide 3	-
FKO10_RS24350	6448..6720	-	273	WP_000167280.1	hypothetical protein	-
FKO10_RS24660	6737..6883	-	147	WP_001567307.1	hypothetical protein	-
FKO10_RS24355	6953..7132	-	180	WP_000439079.1	hypothetical protein	-
FKO10_RS24360	7175..7504	-	330	WP_000866654.1	hypothetical protein	-
FKO10_RS24365	7598..7840	-	243	WP_000008708.1	hypothetical protein	-
FKO10_RS24370	7830..8042	-	213	WP_001446884.1	hypothetical protein	-
FKO10_RS24375	8108..8657	-	550	Protein_15	hypothetical protein	-
FKO10_RS24380	8731..9246	-	516	WP_001025387.1	J domain-containing protein	-
FKO10_RS24385	9596..9877	-	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FKO10_RS24390	9867..10118	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
FKO10_RS24395	11183..12052	+	870	WP_001212191.1	replication initiation protein	-
FKO10_RS24400	12057..12908	+	852	WP_000435059.1	replication initiation protein	-
FKO10_RS24405	12912..13358	+	447	WP_001074378.1	hypothetical protein	-
FKO10_RS24410	13426..13848	+	423	WP_000202950.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..29337	29337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T127758 WP_000220561.1 NZ_CP041175:c9877-9596 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T127758 NZ_CP041175:c9877-9596 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT127758 WP_000121743.1 NZ_CP041175:c10118-9867 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT127758 NZ_CP041175:c10118-9867 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301