127734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 5148453..5149099 Replicon chromosome
Accession NZ_CP041146
Organism Nocardioides humi strain DCY24

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIV44_RS24855 Protein ID WP_141006789.1
Coordinates 5148453..5148842 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIV44_RS24860 Protein ID WP_181410812.1
Coordinates 5148839..5149099 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV44_RS24835 5144308..5144676 + 369 WP_141006786.1 YraN family protein -
FIV44_RS24840 5144676..5146316 + 1641 WP_141006787.1 YifB family Mg chelatase-like AAA ATPase -
FIV44_RS24845 5146313..5147461 + 1149 WP_141006788.1 DNA-processing protein DprA -
FIV44_RS24850 5147512..5148441 + 930 WP_141008053.1 tyrosine recombinase XerC -
FIV44_RS24855 5148453..5148842 - 390 WP_141006789.1 type II toxin-antitoxin system VapC family toxin Toxin
FIV44_RS24860 5148839..5149099 - 261 WP_181410812.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FIV44_RS24865 5149117..5149674 - 558 WP_141006791.1 peptidoglycan DD-metalloendopeptidase family protein -
FIV44_RS24870 5149984..5150931 + 948 WP_141006792.1 30S ribosomal protein S2 -
FIV44_RS24875 5150973..5151781 + 809 Protein_4990 elongation factor Ts -
FIV44_RS24880 5151962..5153185 + 1224 WP_141006793.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-42)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13851.80 Da        Isoelectric Point: 4.4108

>T127734 WP_141006789.1 NZ_CP041146:c5148842-5148453 [Nocardioides humi]
VKAYVDSSAFVKLLVGEPESPALIRYLDQQPDDFQLVSSLLLETEVRRAARANLLDQAAVTAKLTSVTLLDAEHPIFTSA
GLLSPAELRSLDALHLATALDEGVDVLIAYDRRLLDAATVHGITTTSPV

Download         Length: 390 bp

>T127734 NZ_CP041146:c5148842-5148453 [Nocardioides humi]
GTGAAGGCGTATGTCGACTCCTCCGCCTTCGTGAAGCTACTGGTCGGCGAGCCGGAGAGTCCTGCGCTCATTCGCTACTT
GGACCAGCAGCCCGACGACTTCCAGCTGGTCTCCTCGCTGCTGTTGGAGACGGAGGTCAGGCGCGCCGCACGCGCCAATC
TCCTCGATCAGGCGGCTGTCACCGCGAAACTCACTTCGGTCACGCTCCTGGACGCCGAGCACCCGATCTTCACATCGGCG
GGGCTGCTGTCCCCAGCAGAACTGCGCAGTCTCGATGCACTCCACCTGGCAACCGCGCTCGACGAGGGTGTGGATGTCCT
CATCGCCTACGATCGCCGGCTGCTCGACGCCGCCACTGTGCACGGCATCACGACGACTTCACCCGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9775.23 Da        Isoelectric Point: 10.7158

>AT127734 WP_181410812.1 NZ_CP041146:c5149099-5148839 [Nocardioides humi]
VERIPHRELRNNSAEILRRVAAGESFEITNHGEVVAVLNPAARQKFRLKVAKPATRPPRFSLDELKPAPGGRPMQEILDE
LREDRL

Download         Length: 261 bp

>AT127734 NZ_CP041146:c5149099-5148839 [Nocardioides humi]
GTGGAACGGATCCCGCACCGCGAGCTGCGCAACAACAGCGCCGAGATCCTGCGCCGGGTCGCGGCGGGCGAGTCGTTCGA
GATCACCAACCACGGCGAGGTGGTGGCAGTGCTCAATCCTGCAGCGAGACAGAAGTTCCGGCTCAAGGTGGCGAAGCCGG
CCACCCGACCTCCACGCTTCTCTCTCGACGAGTTGAAGCCCGCGCCCGGGGGCCGACCGATGCAGGAGATCCTCGATGAA
CTGCGGGAGGATCGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References