Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4453079..4453655 Replicon chromosome
Accession NZ_CP041146
Organism Nocardioides humi strain DCY24

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FIV44_RS21645 Protein ID WP_141008000.1
Coordinates 4453308..4453655 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FIV44_RS21640 Protein ID WP_141006248.1
Coordinates 4453079..4453321 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV44_RS21620 4449005..4449634 - 630 WP_141006245.1 hypothetical protein -
FIV44_RS21625 4449772..4450767 - 996 WP_141006246.1 type I pantothenate kinase -
FIV44_RS21630 4450850..4452693 + 1844 Protein_4338 glutamine--fructose-6-phosphate transaminase (isomerizing) -
FIV44_RS21635 4452701..4453054 + 354 WP_141006247.1 holo-ACP synthase -
FIV44_RS21640 4453079..4453321 + 243 WP_141006248.1 ribbon-helix-helix domain-containing protein Antitoxin
FIV44_RS21645 4453308..4453655 + 348 WP_141008000.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FIV44_RS21650 4453652..4455031 + 1380 WP_181410753.1 NAD(P)H-hydrate dehydratase -
FIV44_RS21655 4455209..4456389 + 1181 Protein_4343 alanine racemase -
FIV44_RS21660 4456386..4457459 + 1074 WP_141006249.1 alpha/beta hydrolase -
FIV44_RS21665 4457456..4458391 + 936 WP_141006250.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12495.37 Da        Isoelectric Point: 11.1401

>T127733 WP_141008000.1 NZ_CP041146:4453308-4453655 [Nocardioides humi]
VLRGEVRLVDLDPTRGSEASKRRPAVIVSNDRANTTAARLGRGVVTVVPVTSNVSRVLPFQTLLPADETGLRLDSKAQAE
QVRSVAVERLGPVLGRLPSRLVDELDEALRLHLQL

Download         Length: 348 bp

>T127733 NZ_CP041146:4453308-4453655 [Nocardioides humi]
GTGCTGCGGGGTGAGGTCCGACTGGTCGACCTGGATCCGACGCGCGGCAGCGAGGCGAGCAAGCGTCGTCCGGCGGTGAT
CGTCAGCAACGACCGGGCGAACACGACCGCGGCTCGGCTCGGGCGCGGCGTCGTCACCGTCGTACCGGTGACGAGCAACG
TGAGCCGGGTCCTTCCCTTCCAGACGCTGCTCCCCGCCGACGAGACCGGCTTGCGGCTCGACTCGAAGGCGCAGGCCGAG
CAGGTCCGGTCCGTCGCCGTCGAACGGCTCGGACCTGTACTCGGCCGACTCCCGTCACGCCTCGTCGACGAGCTCGACGA
GGCGCTCCGATTGCACCTCCAGCTGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8580.46 Da        Isoelectric Point: 3.9937

>AT127733 WP_141006248.1 NZ_CP041146:4453079-4453321 [Nocardioides humi]
MKLSVSLAADDVALIDEIARRDGLPSRSAVVQRALRQLRIVALEDDYAQAWQEWEESGDAADWDALAGDGLDGTAPRAAG

Download         Length: 243 bp

>AT127733 NZ_CP041146:4453079-4453321 [Nocardioides humi]
ATGAAACTCAGTGTGAGTCTTGCCGCCGACGATGTGGCGCTCATCGACGAGATCGCGCGTCGAGATGGGCTCCCCTCGCG
ATCCGCCGTGGTCCAACGCGCGCTTCGTCAGCTGCGCATCGTCGCCCTCGAGGACGACTACGCGCAGGCGTGGCAGGAGT
GGGAGGAGTCCGGGGACGCCGCCGACTGGGACGCGTTGGCCGGTGACGGTCTCGACGGGACGGCGCCGCGTGCTGCGGGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References