Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 937058..937644 Replicon chromosome
Accession NZ_CP041146
Organism Nocardioides humi strain DCY24

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FIV44_RS04570 Protein ID WP_141003430.1
Coordinates 937058..937405 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FIV44_RS04575 Protein ID WP_141003431.1
Coordinates 937399..937644 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV44_RS04545 932529..933014 + 486 WP_181410989.1 DUF2505 domain-containing protein -
FIV44_RS04550 933016..933498 + 483 WP_141003427.1 DUF2505 domain-containing protein -
FIV44_RS30250 933504..933677 - 174 WP_181410990.1 hypothetical protein -
FIV44_RS04555 933695..935187 - 1493 Protein_926 wax ester/triacylglycerol synthase family O-acyltransferase -
FIV44_RS04560 935333..935701 + 369 WP_141003428.1 hypothetical protein -
FIV44_RS04565 935698..937032 + 1335 WP_141003429.1 hypothetical protein -
FIV44_RS04570 937058..937405 - 348 WP_141003430.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FIV44_RS04575 937399..937644 - 246 WP_141003431.1 CopG family transcriptional regulator Antitoxin
FIV44_RS04580 937686..938906 - 1221 WP_141003432.1 hypothetical protein -
FIV44_RS04585 938923..939579 - 657 WP_141003433.1 hypothetical protein -
FIV44_RS04590 939902..940144 + 243 WP_141003434.1 helix-turn-helix domain-containing protein -
FIV44_RS04595 940177..941601 - 1425 WP_141003435.1 trypsin-like peptidase domain-containing protein -
FIV44_RS04600 941858..942361 - 504 WP_141003436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12184.87 Da        Isoelectric Point: 9.2383

>T127731 WP_141003430.1 NZ_CP041146:c937405-937058 [Nocardioides humi]
VVNRGDVHWCDFGAPSGSGPAKRRPVLVVQSDSYNRSRLATTVVMALTSNTALAAMPGNVFLPATGTGLSKDSVANVTAL
ATVDRRDLDVHPVGRVPDHLMHEVDRGVRQVLALS

Download         Length: 348 bp

>T127731 NZ_CP041146:c937405-937058 [Nocardioides humi]
GTGGTGAACCGTGGCGATGTCCACTGGTGCGACTTCGGTGCTCCGAGCGGGAGCGGCCCGGCCAAGCGGCGTCCTGTCCT
GGTGGTCCAGTCCGACAGCTACAACCGGAGCCGGCTGGCGACCACAGTCGTCATGGCGCTGACCTCGAACACCGCGCTGG
CCGCGATGCCGGGCAACGTATTCCTCCCGGCGACGGGCACCGGGCTGTCGAAGGACTCGGTGGCGAACGTGACGGCACTG
GCGACGGTCGATCGACGCGACCTCGACGTCCATCCGGTGGGCCGGGTGCCGGACCACCTCATGCACGAGGTGGATCGCGG
CGTCCGCCAAGTGCTCGCCCTGTCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8692.54 Da        Isoelectric Point: 4.1353

>AT127731 WP_141003431.1 NZ_CP041146:c937644-937399 [Nocardioides humi]
MKTAISVPDEIFARVERVAGRHGMNRSQFYSAAAERYADELEDADLTAAIDAVADEVNADESSRFAAAAGVRLAAGMADE
W

Download         Length: 246 bp

>AT127731 NZ_CP041146:c937644-937399 [Nocardioides humi]
ATGAAGACCGCCATCTCCGTCCCCGACGAGATCTTCGCGCGCGTCGAGCGAGTCGCGGGCAGGCACGGCATGAACCGCTC
GCAGTTCTACTCCGCAGCGGCGGAGCGCTACGCCGACGAGCTCGAGGACGCCGACCTCACCGCCGCCATCGACGCGGTGG
CGGACGAGGTGAACGCGGACGAGTCGTCCCGGTTCGCCGCGGCCGCCGGAGTTCGGCTGGCGGCAGGGATGGCGGACGAG
TGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References