Detailed information of TA system TA127723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4989452..4990188
• Replicon: chromosome
• Accession: NZ_CP041134
• Organism: Serratia marcescens strain WVU-010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FG175_RS24065
• Protein ID: WP_141960468.1
• Coordinates: 4989709..4990188 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C7DAD3
• Locus tag: FG175_RS24060
• Protein ID: WP_015379309.1
• Coordinates: 4989452..4989712 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG175_RS24040	4985523..4986203	+	681	WP_025304546.1	GMP/IMP nucleotidase	-
FG175_RS24045	4986200..4986607	+	408	WP_015379306.1	ribosome-associated heat shock protein Hsp15	-
FG175_RS24050	4986633..4987511	+	879	WP_015379307.1	Hsp33 family molecular chaperone HslO	-
FG175_RS24055	4987706..4989325	+	1620	WP_015379308.1	phosphoenolpyruvate carboxykinase (ATP)	-
FG175_RS24060	4989452..4989712	+	261	WP_015379309.1	plasmid stability-like protein	Antitoxin
FG175_RS24065	4989709..4990188	+	480	WP_141960468.1	type II toxin-antitoxin system VapC family toxin	Toxin
FG175_RS24070	4990223..4991593	-	1371	WP_038881686.1	two-component system sensor histidine kinase EnvZ	-
FG175_RS24075	4991590..4992309	-	720	WP_004709363.1	two-component system response regulator OmpR	-
FG175_RS24080	4992567..4992872	-	306	WP_049202813.1	chaperone-modulator protein CbpM	-
FG175_RS24085	4992878..4993840	-	963	WP_060424513.1	curved DNA-binding protein	-
FG175_RS24090	4994071..4994544	+	474	WP_038878177.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 18026.69 Da
• Isoelectric Point: 5.9070

>T127723 WP_141960468.1 NZ_CP041134:4989709-4990188 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGVNRRRGIGVSMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T127723 NZ_CP041134:4989709-4990188 [Serratia marcescens]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGCTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCGATGCAGCATGCGGAATTAATGGGCGTCAATCGCCGCCGAGGCATTGGCGTCAGCATGCCGGATACCCAAAT
CGCCGCCACCTGCCTGCATTACGGTGCCGCCCTGGCCACCCGCAACACCAAAGACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAGGATGCGGCGGAATACTACGTGATGAGCAGGAAGTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9907.29 Da
• Isoelectric Point: 5.1898

>AT127723 WP_015379309.1 NZ_CP041134:4989452-4989712 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Nucleotide

• Length: 261 bp

>AT127723 NZ_CP041134:4989452-4989712 [Serratia marcescens]
ATGGCTACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAGCTGCTGCGTATTTCAGCGGCGAAAAACGGCCATTC
TATGGAAGAGGAAGCGCGCATGATCCTGAAACAGGCGCTGGTGAAAAAACCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAAGCCCCTCATCGTATTGTCAACTTT
GATGAAGACGATGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DAD3