Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3916941..3917503 Replicon chromosome
Accession NZ_CP041134
Organism Serratia marcescens strain WVU-010

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FG175_RS19000 Protein ID WP_025303801.1
Coordinates 3916941..3917297 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag FG175_RS19005 Protein ID WP_004936539.1
Coordinates 3917294..3917503 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG175_RS18980 3912676..3913473 - 798 WP_141959878.1 energy transducer TonB -
FG175_RS18985 3913576..3914415 - 840 WP_047571061.1 ChaN family lipoprotein -
FG175_RS18990 3914593..3916002 + 1410 WP_047730133.1 S-methylmethionine permease -
FG175_RS18995 3915992..3916930 + 939 WP_141959880.1 homocysteine S-methyltransferase -
FG175_RS19000 3916941..3917297 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FG175_RS19005 3917294..3917503 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FG175_RS19010 3917613..3919892 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
FG175_RS19015 3920107..3920316 - 210 WP_141960708.1 hypothetical protein -
FG175_RS19020 3920261..3920641 - 381 WP_084827301.1 DUF2570 family protein -
FG175_RS19025 3920638..3921039 - 402 WP_019453868.1 M15 family metallopeptidase -
FG175_RS19030 3921029..3921355 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T127716 WP_025303801.1 NZ_CP041134:c3917297-3916941 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T127716 NZ_CP041134:c3917297-3916941 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTTTACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCTGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT127716 WP_004936539.1 NZ_CP041134:c3917503-3917294 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT127716 NZ_CP041134:c3917503-3917294 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References