Detailed information of TA system TA127700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4989483..4990219
• Replicon: chromosome
• Accession: NZ_CP041130
• Organism: Serratia marcescens strain WVU-007

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FG172_RS24065
• Protein ID: WP_141960468.1
• Coordinates: 4989740..4990219 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C7DAD3
• Locus tag: FG172_RS24060
• Protein ID: WP_015379309.1
• Coordinates: 4989483..4989743 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG172_RS24040	4985554..4986234	+	681	WP_025304546.1	GMP/IMP nucleotidase	-
FG172_RS24045	4986231..4986638	+	408	WP_015379306.1	ribosome-associated heat shock protein Hsp15	-
FG172_RS24050	4986664..4987542	+	879	WP_015379307.1	Hsp33 family molecular chaperone HslO	-
FG172_RS24055	4987737..4989356	+	1620	WP_015379308.1	phosphoenolpyruvate carboxykinase (ATP)	-
FG172_RS24060	4989483..4989743	+	261	WP_015379309.1	plasmid stability-like protein	Antitoxin
FG172_RS24065	4989740..4990219	+	480	WP_141960468.1	type II toxin-antitoxin system VapC family toxin	Toxin
FG172_RS24070	4990254..4991624	-	1371	WP_038881686.1	two-component system sensor histidine kinase EnvZ	-
FG172_RS24075	4991621..4992340	-	720	WP_004709363.1	two-component system response regulator OmpR	-
FG172_RS24080	4992598..4992903	-	306	WP_049202813.1	chaperone-modulator protein CbpM	-
FG172_RS24085	4992909..4993871	-	963	WP_060424513.1	curved DNA-binding protein	-
FG172_RS24090	4994102..4994575	+	474	WP_038878177.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 18026.69 Da
• Isoelectric Point: 5.9070

>T127700 WP_141960468.1 NZ_CP041130:4989740-4990219 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGVNRRRGIGVSMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T127700 NZ_CP041130:4989740-4990219 [Serratia marcescens]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGCTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCGATGCAGCATGCGGAATTAATGGGCGTCAATCGCCGCCGAGGCATTGGCGTCAGCATGCCGGATACCCAAAT
CGCCGCCACCTGCCTGCATTACGGTGCCGCCCTGGCCACCCGCAACACCAAAGACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAGGATGCGGCGGAATACTACGTGATGAGCAGGAAGTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9907.29 Da
• Isoelectric Point: 5.1898

>AT127700 WP_015379309.1 NZ_CP041130:4989483-4989743 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Nucleotide

• Length: 261 bp

>AT127700 NZ_CP041130:4989483-4989743 [Serratia marcescens]
ATGGCTACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAGCTGCTGCGTATTTCAGCGGCGAAAAACGGCCATTC
TATGGAAGAGGAAGCGCGCATGATCCTGAAACAGGCGCTGGTGAAAAAACCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAAGCCCCTCATCGTATTGTCAACTTT
GATGAAGACGATGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DAD3