Detailed information of TA system TA127697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4528194..4528666
• Replicon: chromosome
• Accession: NZ_CP041130
• Organism: Serratia marcescens strain WVU-007

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: FG172_RS21875
• Protein ID: WP_049208401.1
• Coordinates: 4528194..4528469 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FG172_RS21880
• Protein ID: WP_141960248.1
• Coordinates: 4528475..4528666 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG172_RS21850	4523514..4524794	-	1281	WP_055311947.1	polysaccharide deacetylase family protein	-
FG172_RS21855	4524972..4525742	-	771	WP_004937535.1	ABC transporter permease	-
FG172_RS21860	4525739..4526662	-	924	WP_033644695.1	ABC transporter ATP-binding protein	-
FG172_RS21865	4526873..4527529	+	657	WP_049200096.1	carbonate dehydratase	-
FG172_RS21870	4527567..4528103	-	537	WP_048234659.1	hypoxanthine phosphoribosyltransferase	-
FG172_RS21875	4528194..4528469	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FG172_RS21880	4528475..4528666	-	192	WP_141960248.1	stability determinant	Antitoxin
FG172_RS21885	4528772..4530472	-	1701	WP_141960250.1	multicopper oxidase CueO	-
FG172_RS21890	4530691..4531038	+	348	WP_004937515.1	YacC family pilotin-like protein	-
FG172_RS21895	4531163..4532026	+	864	WP_070913726.1	polyamine aminopropyltransferase	-
FG172_RS21900	4532054..4532848	+	795	WP_049200100.1	adenosylmethionine decarboxylase	-
FG172_RS21905	4532881..4533243	-	363	WP_004937507.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T127697 WP_049208401.1 NZ_CP041130:c4528469-4528194 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T127697 NZ_CP041130:c4528469-4528194 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCAGAGGCTTTGTTGCAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCAGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7161.95 Da
• Isoelectric Point: 5.6492

>AT127697 WP_141960248.1 NZ_CP041130:c4528666-4528475 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSISSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT127697 NZ_CP041130:c4528666-4528475 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAGTAGCGACTCCCCCCGTATTCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428