Detailed information of TA system TA127696

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4412272..4412941
• Replicon: chromosome
• Accession: NZ_CP041130
• Organism: Serratia marcescens strain WVU-007

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FG172_RS21320
• Protein ID: WP_060422869.1
• Coordinates: 4412272..4412694 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: FG172_RS21325
• Protein ID: WP_019455657.1
• Coordinates: 4412675..4412941 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG172_RS21300	4408162..4408680	+	519	WP_048324740.1	flavodoxin FldB	-
FG172_RS21305	4408717..4410081	-	1365	WP_141960175.1	cell envelope integrity protein CreD	-
FG172_RS21310	4410162..4411580	-	1419	WP_141960177.1	two-component system sensor histidine kinase CreC	-
FG172_RS21315	4411577..4412272	-	696	WP_033644777.1	two-component system response regulator CreB	-
FG172_RS21320	4412272..4412694	-	423	WP_060422869.1	protein YgfX	Toxin
FG172_RS21325	4412675..4412941	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
FG172_RS21330	4413262..4414254	+	993	WP_141960178.1	tRNA-modifying protein YgfZ	-
FG172_RS21335	4414293..4414790	-	498	WP_141960180.1	DUF2165 domain-containing protein	-
FG172_RS21340	4414941..4415615	-	675	WP_038871224.1	hemolysin III family protein	-
FG172_RS21345	4415799..4416407	+	609	WP_060422860.1	HD domain-containing protein	-
FG172_RS21350	4416440..4417366	-	927	WP_141960182.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16438.50 Da
• Isoelectric Point: 10.8114

>T127696 WP_060422869.1 NZ_CP041130:c4412694-4412272 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T127696 NZ_CP041130:c4412694-4412272 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTGGGCCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAAAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGTTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGTGAGGAGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT127696 WP_019455657.1 NZ_CP041130:c4412941-4412675 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT127696 NZ_CP041130:c4412941-4412675 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04