Detailed information of TA system TA127695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 4403899..4404622
• Replicon: chromosome
• Accession: NZ_CP041130
• Organism: Serratia marcescens strain WVU-007

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FG172_RS21275
• Protein ID: WP_141960171.1
• Coordinates: 4403899..4404285 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FG172_RS21280
• Protein ID: WP_060422882.1
• Coordinates: 4404278..4404622 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (54-91)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14515.51 Da
• Isoelectric Point: 9.0115

>T127695 WP_141960171.1 NZ_CP041130:4403899-4404285 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAQGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGHHQYFVDGWLKNA
VKQSGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Nucleotide

• Length: 387 bp

>T127695 NZ_CP041130:4403899-4404285 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACGGCGGC
TCACGAACTCGCGCAAGGTAACCATGACGGCGATCTGGGCGGTGGCGTCTACAAGAAGCGCATTTCGCTCAATCGGGGTA
AACGGGGTGGAGCCCGATCCATCGTGGCGTTTAAACGCGGACATCATCAGTATTTTGTTGATGGGTGGCTGAAAAACGCC
GTAAAACAGAGCGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12979.97 Da
• Isoelectric Point: 11.6257

>AT127695 WP_060422882.1 NZ_CP041130:4404278-4404622 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEVGAVSDDTMRNITARVQAQEQHARREQHEQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Nucleotide

• Length: 345 bp

>AT127695 NZ_CP041130:4404278-4404622 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGGTCGGTGCCGTGTCAGACGACACAAT
GCGCAACATCACTGCGCGAGTTCAGGCGCAGGAACAACATGCCCGGCGTGAACAGCATGAGCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTCGGCCTGAGCCAGGCCGATTTGGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAGATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCGCCACGAAACTGA