Detailed information of TA system TA127695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 4403899..4404622
• Replicon: chromosome
• Accession: NZ_CP041130
• Organism: Serratia marcescens strain WVU-007

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FG172_RS21275
• Protein ID: WP_141960171.1
• Coordinates: 4403899..4404285 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FG172_RS21280
• Protein ID: WP_060422882.1
• Coordinates: 4404278..4404622 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG172_RS21265	4401012..4402529	-	1518	WP_033649459.1	lysine--tRNA ligase	-
FG172_RS21275	4403899..4404285	+	387	WP_141960171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FG172_RS21280	4404278..4404622	+	345	WP_060422882.1	helix-turn-helix domain-containing protein	Antitoxin
FG172_RS21285	4404673..4406406	-	1734	WP_060422879.1	single-stranded-DNA-specific exonuclease RecJ	-
FG172_RS21290	4406413..4407129	-	717	WP_141960173.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FG172_RS21295	4407156..4408055	-	900	WP_141960742.1	site-specific tyrosine recombinase XerD	-
FG172_RS21300	4408162..4408680	+	519	WP_048324740.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (54-91)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14515.51 Da
• Isoelectric Point: 9.0115

>T127695 WP_141960171.1 NZ_CP041130:4403899-4404285 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAQGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGHHQYFVDGWLKNA
VKQSGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Nucleotide

• Length: 387 bp

>T127695 NZ_CP041130:4403899-4404285 [Serratia marcescens]
ATGGACATTTTCGTCACGGATGATTTCGACAAATTTATGAAGAAAAATCGCATCGTCGATCAAAAGATTTGCACGGCGGC
TCACGAACTCGCGCAAGGTAACCATGACGGCGATCTGGGCGGTGGCGTCTACAAGAAGCGCATTTCGCTCAATCGGGGTA
AACGGGGTGGAGCCCGATCCATCGTGGCGTTTAAACGCGGACATCATCAGTATTTTGTTGATGGGTGGCTGAAAAACGCC
GTAAAACAGAGCGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCGCCAGAGATTTTCTTGCCAT
GCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGATGACTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12979.97 Da
• Isoelectric Point: 11.6257

>AT127695 WP_060422882.1 NZ_CP041130:4404278-4404622 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEVGAVSDDTMRNITARVQAQEQHARREQHEQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Nucleotide

• Length: 345 bp

>AT127695 NZ_CP041130:4404278-4404622 [Serratia marcescens]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGGTCGGTGCCGTGTCAGACGACACAAT
GCGCAACATCACTGCGCGAGTTCAGGCGCAGGAACAACATGCCCGGCGTGAACAGCATGAGCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTCGGCCTGAGCCAGGCCGATTTGGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAGATTATCGAACAGAAAGGGGTCGCCAG
CCTGATCATCTCGCCACGAAACTGA